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CRISPR-Cas enzymes: The toolkit revolutionizing diagnostics.
Verosloff, Matthew S; Shapiro, Sarah J; Hawkins, Elizabeth M; Alpay, Emel; Verma, Deepika; Stanfield, Emma G; Kreindler, Lior; Jain, Sonal; McKay, Bridget; Hubbell, Shae A; Hendriks, Carley G; Blizard, Benjamin A; Broughton, James P; Chen, Janice S.
  • Verosloff MS; Mammoth Biosciences, Inc., Brisbane, California, USA.
  • Shapiro SJ; Mammoth Biosciences, Inc., Brisbane, California, USA.
  • Hawkins EM; Mammoth Biosciences, Inc., Brisbane, California, USA.
  • Alpay E; Mammoth Biosciences, Inc., Brisbane, California, USA.
  • Verma D; Mammoth Biosciences, Inc., Brisbane, California, USA.
  • Stanfield EG; Mammoth Biosciences, Inc., Brisbane, California, USA.
  • Kreindler L; Mammoth Biosciences, Inc., Brisbane, California, USA.
  • Jain S; Mammoth Biosciences, Inc., Brisbane, California, USA.
  • McKay B; Mammoth Biosciences, Inc., Brisbane, California, USA.
  • Hubbell SA; Mammoth Biosciences, Inc., Brisbane, California, USA.
  • Hendriks CG; Mammoth Biosciences, Inc., Brisbane, California, USA.
  • Blizard BA; Mammoth Biosciences, Inc., Brisbane, California, USA.
  • Broughton JP; Mammoth Biosciences, Inc., Brisbane, California, USA.
  • Chen JS; Mammoth Biosciences, Inc., Brisbane, California, USA.
Biotechnol J ; 17(7): e2100304, 2022 Jul.
Article in English | MEDLINE | ID: covidwho-1400751
ABSTRACT
The programmable nature of sequence-specific targeting by CRISPR-Cas nucleases has revolutionized a wide range of genomic applications and is now emerging as a method for nucleic acid detection. We explore how the diversity of CRISPR systems and their fundamental mechanisms have given rise to a wave of new methods for target recognition and readout. These cross-disciplinary advances found at the intersection of CRISPR biology and engineering have led to the ability to rapidly generate solutions for emerging global challenges like the COVID-19 pandemic. We further discuss the advances and potential for CRISPR-based detection to have an impact across a continuum of diagnostic applications.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: CRISPR-Cas Systems / COVID-19 Type of study: Diagnostic study / Randomized controlled trials Limits: Humans Language: English Journal: Biotechnol J Journal subject: Biotechnology Year: 2022 Document Type: Article Affiliation country: Biot.202100304

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Full text: Available Collection: International databases Database: MEDLINE Main subject: CRISPR-Cas Systems / COVID-19 Type of study: Diagnostic study / Randomized controlled trials Limits: Humans Language: English Journal: Biotechnol J Journal subject: Biotechnology Year: 2022 Document Type: Article Affiliation country: Biot.202100304