Effect of melatonin supplementation on endothelial function in heart failure with reduced ejection fraction: A randomized, double-blinded clinical trial.
Clin Cardiol
; 44(9): 1263-1271, 2021 Sep.
Article
in English
| MEDLINE | ID: covidwho-1400778
ABSTRACT
BACKGROUND:
This study aimed to investigate the effect of melatonin supplementation on endothelial function in patients with heart failure with reduced ejection fraction (HFrEF).METHODS:
This is an analysis of the MeHR trial, a randomized double-blinded placebo-controlled clinical trial with two parallel arms of 11. Oral 10 mg melatonin tablets or placebo was administered for 24 weeks. Deference in the percentage of flow-mediated dilatation (FMD) after the intervention was the primary outcome.RESULTS:
Ninety-two patients were included in the study (age 62.7±10.3 years, 87.0% male, ejection fraction (EF) 28.6±8.1). After adjustment for baseline FMD and age, a statistically significant difference in post-treatment FMD in favor of the melatonin group was seen (estimated marginal means [95%CI], melatonin 7.84% [6.69-8.98], placebo 5.98% [4.84-7.12], p = .027). There was no significant difference in the mean of post-treatment systolic/diastolic blood pressure, serum total antioxidant capacity, and serum malondialdehyde (MDA) between groups. Subgroup analysis showed significant improvement in FMD and MDA in the melatonin group in nondiabetic patients, while no difference was seen between study groups in diabetic patients.CONCLUSIONS:
Melatonin supplementation in HFrEF might improve endothelial function; however, this beneficial effect might not be seen in diabetic patients.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Heart Failure
/
Melatonin
Type of study:
Diagnostic study
/
Experimental Studies
/
Prognostic study
/
Randomized controlled trials
Topics:
Traditional medicine
Limits:
Female
/
Humans
/
Male
/
Middle aged
Language:
English
Journal:
Clin Cardiol
Year:
2021
Document Type:
Article
Affiliation country:
Clc.23682
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