Host proviral and antiviral factors for SARS-CoV-2.
Virus Genes
; 57(6): 475-488, 2021 Dec.
Article
in English
| MEDLINE | ID: covidwho-1401067
ABSTRACT
Throughout the viral life cycle, interplays between cellular host factors and virus determine the infectious capacity of the virus. The pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses a great threat to human life and health. Extensive studies identified a number of host proviral and antiviral factors for SARS-CoV-2. In this review, we summarize the current understanding of the interplay between SARS-CoV-2 and cellular factors during virus entry and replication. Our review will highlight the future direction of study on the infection and pathogenesis of SARS-CoV-2, as well as novel therapeutic strategies and effective antiviral targets for COVID-19.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Virus Replication
/
Virus Internalization
/
Host Microbial Interactions
/
SARS-CoV-2
/
COVID-19
Limits:
Animals
/
Humans
Language:
English
Journal:
Virus Genes
Journal subject:
Molecular Biology
/
Virology
Year:
2021
Document Type:
Article
Affiliation country:
S11262-021-01869-2
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