Upping the ante on mammalian antiviral RNA interference.

Jeffrey, Kate L

Jeffrey, Kate L.

Jeffrey KL; Division of Gastroenterology and Center for the Study of Inflammatory Bowel Disease, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. Electronic address: kjeffrey@mgh.harvard.edu.

Cell Host Microbe ; 29(9): 1333-1335, 2021 09 08.

Article in English | MEDLINE | ID: covidwho-1401314

ABSTRACT

ABSTRACT

SARS-CoV-2 has mutually illuminated our collective knowledge and knowledge gaps, particularly in antiviral defense and therapeutic strategies. A recent study in Science (Poirier et al., 2021) uncovers an ancient antiviral mechanism that mammals utilize to suppress viruses, including SARS-CoV-2 and Zika virus, that could have broad implications for therapeutic strategies.

Subject(s)

Argonaute Proteins/metabolism; COVID-19/prevention & control; Interferons/immunology; RNA Interference/physiology; Ribonuclease III/metabolism; Zika Virus Infection/prevention & control; Animals; Cell Line; HEK293 Cells; Humans; RNA, Small Interfering/genetics; RNA, Viral/metabolism; SARS-CoV-2/genetics; SARS-CoV-2/immunology; Virus Replication; Zika Virus/genetics; Zika Virus/immunology

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Interferons / RNA Interference / Ribonuclease III / Argonaute Proteins / Zika Virus Infection / COVID-19 Limits: Animals / Humans Language: English Journal: Cell Host Microbe Journal subject: Microbiology Year: 2021 Document Type: Article

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