Immunodominance complexity: lessons yet to be learned from dominant T cell responses to SARS-COV-2.
Curr Opin Virol
; 50: 183-191, 2021 10.
Article
in English
| MEDLINE | ID: covidwho-1401390
ABSTRACT
Immunodominance is a complex and highly debated topic of T cell biology. The current SARS-CoV-2 pandemic has provided the opportunity to profile adaptive immune responses and determine molecular factors contributing to emerging responses towards immunodominant viral epitopes. Here, we discuss parameters that alter the dynamics of CD8 viral epitope processing, generation and T-cell responses, and how immunodominance counteracts viral immune escape mechanisms that develop in the context of emerging SARS-CoV-2 variants.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
T-Lymphocytes
/
Immunodominant Epitopes
/
SARS-CoV-2
Topics:
Variants
Limits:
Humans
Language:
English
Journal:
Curr Opin Virol
Year:
2021
Document Type:
Article
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