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SARS-CoV-2 wastewater surveillance data can predict hospitalizations and ICU admissions.
Galani, Aikaterini; Aalizadeh, Reza; Kostakis, Marios; Markou, Athina; Alygizakis, Nikiforos; Lytras, Theodore; Adamopoulos, Panagiotis G; Peccia, Jordan; Thompson, David C; Kontou, Aikaterini; Karagiannidis, Apostolos; Lianidou, Evi S; Avgeris, Margaritis; Paraskevis, Dimitrios; Tsiodras, Sotirios; Scorilas, Andreas; Vasiliou, Vasilis; Dimopoulos, Meletios-Athanasios; Thomaidis, Nikolaos S.
  • Galani A; Laboratory of Analytical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, University Campus, Zografou, 15771, Athens, Greece.
  • Aalizadeh R; Laboratory of Analytical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, University Campus, Zografou, 15771, Athens, Greece.
  • Kostakis M; Laboratory of Analytical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, University Campus, Zografou, 15771, Athens, Greece.
  • Markou A; Laboratory of Analytical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, University Campus, Zografou, 15771, Athens, Greece.
  • Alygizakis N; Laboratory of Analytical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, University Campus, Zografou, 15771, Athens, Greece.
  • Lytras T; School of Medicine, European University Cyprus, Cyprus.
  • Adamopoulos PG; Department of Biochemistry and Molecular Biology, Faculty of Biology, National and Kapodistrian University of Athens, Athens, Greece.
  • Peccia J; Department of Chemical and Environmental Engineering, School of Engineering and Applied Science, Yale University, New Haven, CT, USA.
  • Thompson DC; Department of Clinical Pharmacy, School of Pharmacy and Pharmaceutical Sciences, University of Colorado Skaggs, Aurora, CO, USA; Department of Environmental Health Sciences, Yale School of Public Health, Yale University, New Haven, CT 06510, USA.
  • Kontou A; Laboratory of Analytical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, University Campus, Zografou, 15771, Athens, Greece.
  • Karagiannidis A; Laboratory of Analytical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, University Campus, Zografou, 15771, Athens, Greece.
  • Lianidou ES; Laboratory of Analytical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, University Campus, Zografou, 15771, Athens, Greece.
  • Avgeris M; Department of Biochemistry and Molecular Biology, Faculty of Biology, National and Kapodistrian University of Athens, Athens, Greece; Laboratory of Clinical Biochemistry - Molecular Diagnostics, Second Department of Pediatrics, "P. & A. Kyriakou" Children's Hospital, School of Medicine, National
  • Paraskevis D; Department of Hygiene Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece.
  • Tsiodras S; Fourth Department of Internal Medicine, School of Medicine, University General Hospital Attikon, National and Kapodistrian University of Athens, Greece.
  • Scorilas A; Department of Biochemistry and Molecular Biology, Faculty of Biology, National and Kapodistrian University of Athens, Athens, Greece.
  • Vasiliou V; Department of Environmental Health Sciences, Yale School of Public Health, Yale University, New Haven, CT 06510, USA.
  • Dimopoulos MA; Department of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens, Greece.
  • Thomaidis NS; Laboratory of Analytical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, University Campus, Zografou, 15771, Athens, Greece. Electronic address: ntho@chem.uoa.gr.
Sci Total Environ ; 804: 150151, 2022 Jan 15.
Article in English | MEDLINE | ID: covidwho-1401851
ABSTRACT
We measured SARS-CoV-2 RNA load in raw wastewater in Attica, Greece, by RT-qPCR for the environmental surveillance of COVID-19 for 6 months. The lag between RNA load and pandemic indicators (COVID-19 hospital and intensive care unit (ICU) admissions) was calculated using a grid search. Our results showed that RNA load in raw wastewater is a leading indicator of positive COVID-19 cases, new hospitalization and admission into ICUs by 5, 8 and 9 days, respectively. Modelling techniques based on distributed/fixed lag modelling, linear regression and artificial neural networks were utilized to build relationships between SARS-CoV-2 RNA load in wastewater and pandemic health indicators. SARS-CoV-2 mutation analysis in wastewater during the third pandemic wave revealed that the alpha-variant was dominant. Our results demonstrate that clinical and environmental surveillance data can be combined to create robust models to study the on-going COVID-19 infection dynamics and provide an early warning for increased hospital admissions.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Prognostic study Topics: Variants Limits: Humans Language: English Journal: Sci Total Environ Year: 2022 Document Type: Article Affiliation country: J.scitotenv.2021.150151

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Prognostic study Topics: Variants Limits: Humans Language: English Journal: Sci Total Environ Year: 2022 Document Type: Article Affiliation country: J.scitotenv.2021.150151