Uncovering viral RNA-host cell interactions on a proteome-wide scale.
Trends Biochem Sci
; 47(1): 23-38, 2022 01.
Article
in English
| MEDLINE | ID: covidwho-1401892
ABSTRACT
RNA viruses interact with a wide range of cellular RNA-binding proteins (RBPs) during their life cycle. The prevalence of these host-virus interactions has been highlighted by new methods that elucidate the composition of viral ribonucleoproteins (vRNPs). Applied to 11 viruses so far, these approaches have revealed hundreds of cellular RBPs that interact with viral (v)RNA in infected cells. However, consistency across methods is limited, raising questions about methodological considerations when designing and interpreting these studies. Here, we discuss these caveats and, through comparing available vRNA interactomes, describe RBPs that are consistently identified as vRNP components and outline their potential roles in infection. In summary, these novel approaches have uncovered a new universe of host-virus interactions holding great therapeutic potential.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
RNA, Viral
/
Proteome
Type of study:
Observational study
Language:
English
Journal:
Trends Biochem Sci
Year:
2022
Document Type:
Article
Affiliation country:
J.tibs.2021.08.002
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