Patients from COVID-19 mostly recover from tubular proteinuria and acute kidney injury after hospital discharge
Nephrology Dialysis Transplantation
; 36(SUPPL 1):i318, 2021.
Article
in English
| EMBASE | ID: covidwho-1402442
ABSTRACT
BACKGROUND AND AIMS:
Proteinuria, hematuria and acute kidney injury (AKI) are frequently observed in hospitalized patients with COVID-19. However, few data are available on these parameters after hospital discharge.METHOD:
This retrospective, observational and monocentric study included 153 hospitalized patients, in whom urine total proteinuria and a1-microglobulin (a marker of tubular injury) were measured. Thirty patients died. Among the 123 survivors, follow-up urine and creatinine analyses were available for 72 patients (after a median of 51 [19;93] days following hospital discharge).RESULTS:
The median proteinuria at hospitalization and follow-up (n=72) was 419 [239;748] and 79 [47;129] mg/g, respectively (p<0.0001). The median concentrations of urinary a1-microglobulin (n=66) were 50 [25;81] and 8 [0;19] mg/g, respectively (p<0.0001). Estimating glomerular filtration rate (eGFR) was lower during the hospitalization compared to the follow-up 81 [62;92] versus 87 [66;98] mL/min/ 1.73m2 (p=0.0222). At follow-up, a decreased renal function was observed in 10/72 (14%) of patients, with 50% of them presenting decreased renal function before COVID-19 hospitalization and others developing severe AKI and/or proteinuria during hospitalization.CONCLUSION:
In most hospitalized patients with COVID-19, proteinuria and eGFR significantly improved after hospital discharge. Only patients who developed severe AKI and/or heavy proteinuria will require a specific follow-up by nephrologists.
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Language:
English
Journal:
Nephrology Dialysis Transplantation
Year:
2021
Document Type:
Article
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