Interleukin-1RA Mitigates SARS-CoV-2-Induced Inflammatory Lung Vascular Leakage and Mortality in Humanized K18-hACE-2 Mice.

Xiong, Shiqin; Zhang, Lianghui; Richner, Justin M; Class, Jake; Rehman, Jalees; Malik, Asrar B

Xiong, Shiqin; Zhang, Lianghui; Richner, Justin M; Class, Jake; Rehman, Jalees; Malik, Asrar B.

Xiong S; Department of Pharmacology and Regenerative Medicine and the Center for Lung and Vascular Biology (S.X., L.Z., J.R., A.B.M.), University of Illinois College of Medicine at Chicago.
Zhang L; Now with Department of Cardiometabolic Diseases, Merck Research Laboratories, South San Francisco, CA (S.X.).
Richner JM; Department of Pharmacology and Regenerative Medicine and the Center for Lung and Vascular Biology (S.X., L.Z., J.R., A.B.M.), University of Illinois College of Medicine at Chicago.
Class J; Department of Microbiology and Immunology (J.M.R., J.C.), University of Illinois College of Medicine at Chicago.
Rehman J; Division of Cardiology, Department of Medicine (J.R.), University of Illinois College of Medicine at Chicago.
Malik AB; Department of Microbiology and Immunology (J.M.R., J.C.), University of Illinois College of Medicine at Chicago.

Arterioscler Thromb Vasc Biol ; 41(11): 2773-2785, 2021 11.

Article in English | MEDLINE | ID: covidwho-1403146

ABSTRACT

ABSTRACT

[Figure see text].

Subject(s)

COVID-19 Drug Treatment; COVID-19/physiopathology; Interleukin 1 Receptor Antagonist Protein/therapeutic use; Receptors, Interleukin-1/physiology; Animals; Antigens, CD/metabolism; COVID-19/complications; Cadherins/metabolism; Capillary Permeability; Caspase 1/metabolism; Disease Models, Animal; Down-Regulation/drug effects; Edema/physiopathology; Edema/prevention & control; Endothelium, Vascular/drug effects; Enzyme Activation; Fibrosis/prevention & control; Mice, Inbred C57BL; Mice, Transgenic; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism; Neutrophils/physiology; Pulmonary Circulation; Receptors, Interleukin-1/antagonists & inhibitors; SARS-CoV-2; Signal Transduction/drug effects

Keywords

SARS-CoV-2; edema; ies; interleukin-1; pyroptosis; vascular system injur

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Receptors, Interleukin-1 / Interleukin 1 Receptor Antagonist Protein / COVID-19 / COVID-19 Drug Treatment Topics: Long Covid Limits: Animals Language: English Journal: Arterioscler Thromb Vasc Biol Journal subject: Vascular Diseases Year: 2021 Document Type: Article

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