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Elevated C-reactive protein in early COVID-19 predicts worse survival among hospitalized geriatric patients.
Villoteau, Adeline; Asfar, Marine; Otekpo, Marie; Loison, Jocelyne; Gautier, Jennifer; Annweiler, Cédric.
  • Villoteau A; School of Medicine, Health Faculty, University of Angers, Angers, France.
  • Asfar M; Department of Geriatric Medicine and Memory Clinic, Research Center on Autonomy and Longevity, University Hospital, Angers, France.
  • Otekpo M; School of Medicine, Health Faculty, University of Angers, Angers, France.
  • Loison J; Department of Geriatric Medicine and Memory Clinic, Research Center on Autonomy and Longevity, University Hospital, Angers, France.
  • Gautier J; School of Medicine, Health Faculty, University of Angers, Angers, France.
  • Annweiler C; Department of Geriatric Medicine and Memory Clinic, Research Center on Autonomy and Longevity, University Hospital, Angers, France.
PLoS One ; 16(9): e0256931, 2021.
Article in English | MEDLINE | ID: covidwho-1403305
ABSTRACT

BACKGROUND:

The objective of this cohort study was to determine whether elevated CRP in early COVID-19 was associated with 14-day mortality in geriatric patients.

METHODS:

Plasma CRP levels at hospital admission and 14-day all-cause mortality were assessed in geriatric inpatients hospitalized for COVID-19. Potential confounders were age, sex, functional abilities, history of malignancies, hypertension, cardiomyopathy, albuminemia, number of acute health issues, use of antibiotics and respiratory treatments.

RESULTS:

Ninety-five participants (mean±SD 88.0±5.5years; 49.5%women; mean CRP, 76.7±77.5mg/L; mean albuminemia, 32.9±6.0g/L) were included. Sixteen participants who did not survive at day 14 exhibited higher CRP level at baseline than the others (120.3±71.2 versus 67.9±76.1 mg/L, P = 0.002). There was no difference in albuminemia (P = 0.329). Plasma CRP level was directly associated with 14-day mortality (fully adjusted HR = 1.11, P = 0.025). The cut-off for CRP associated with 14-day mortality was set at 35mg/L (sensitivity = 0.88; specificity = 0.56). Those with CRP<35mg/L had longer survival time than the others (log-rank P<0.001).

CONCLUSIONS:

Elevated CRP levels were associated with poorer 14-day survival in hospitalized geriatric COVID-19 patients.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Receptors, Immunologic / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Limits: Female / Humans / Male Language: English Journal: PLoS One Journal subject: Science / Medicine Year: 2021 Document Type: Article Affiliation country: Journal.pone.0256931

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Receptors, Immunologic / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Limits: Female / Humans / Male Language: English Journal: PLoS One Journal subject: Science / Medicine Year: 2021 Document Type: Article Affiliation country: Journal.pone.0256931