Your browser doesn't support javascript.
Elevated Neopterin Levels Predict Fatal Outcome in SARS-CoV-2-Infected Patients.
Chauvin, Manon; Larsen, Martin; Quirant, Bibiana; Quentric, Paul; Dorgham, Karim; Royer, Luca; Vallet, Hélène; Guihot, Amelie; Combadière, Béhazine; Combadière, Christophe; Barallat, Jaume; Mayaux, Julien; Luyt, Charles-Edouard; Mathian, Alexis; Amoura, Zahir; Boddaert, Jacques; Armestar, Fernando; Gorochov, Guy; Martinez-Caceres, Eva; Sauce, Delphine.
  • Chauvin M; Sorbonne Université, Inserm, Centre d'Immunologie et des Maladies Infectieuses, Cimi-Paris, Paris, France.
  • Larsen M; Sorbonne Université, Inserm, Centre d'Immunologie et des Maladies Infectieuses, Cimi-Paris, Paris, France.
  • Quirant B; Division of Immunology, Germans Trias i Pujol University Hospital and Research Institute, Badalona, Spain.
  • Quentric P; Department of Cellular Biology, Physiology and Immunology, Universitat Autònoma de Barcelona, Bellaterra (Cerdanyola del Vallès), Spain.
  • Dorgham K; Sorbonne Université, Inserm, Centre d'Immunologie et des Maladies Infectieuses, Cimi-Paris, Paris, France.
  • Royer L; Sorbonne Université, Inserm, Centre d'Immunologie et des Maladies Infectieuses, Cimi-Paris, Paris, France.
  • Vallet H; Sorbonne Université, Inserm, Centre d'Immunologie et des Maladies Infectieuses, Cimi-Paris, Paris, France.
  • Guihot A; Sorbonne Université, Inserm, Centre d'Immunologie et des Maladies Infectieuses, Cimi-Paris, Paris, France.
  • Combadière B; Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Saint-Antoine, Unité de Gériatrie Aigue, Paris, France.
  • Combadière C; Sorbonne Université, Inserm, Centre d'Immunologie et des Maladies Infectieuses, Cimi-Paris, Paris, France.
  • Barallat J; Assistance Publique-Hôpitaux de Paris (AP-HP), Groupement Hospitalier Pitié-Salpêtrière, Département d'Immunologie, Paris, France.
  • Mayaux J; Sorbonne Université, Inserm, Centre d'Immunologie et des Maladies Infectieuses, Cimi-Paris, Paris, France.
  • Luyt CE; Sorbonne Université, Inserm, Centre d'Immunologie et des Maladies Infectieuses, Cimi-Paris, Paris, France.
  • Mathian A; Biochemistry Department, Germans Trias i Pujol University Hospital, Badalona, Spain.
  • Amoura Z; Assistance Publique-Hôpitaux de Paris (AP-HP), Groupement Hospitalier Pitié-Salpêtrière, Service de Médecine Intensive-Réanimation et Pneumologie, Paris, France.
  • Boddaert J; Service de Médecine Intensive Réanimation, Institut de Cardiologie, Assistance Publique-Hôpitaux de Paris (APHP), Sorbonne-Université, Service de Médecine Intensive-Réanimation et Pneumologie, Paris, France.
  • Armestar F; Sorbonne Université, Inserm, Centre d'Immunologie et des Maladies Infectieuses, Cimi-Paris, Paris, France.
  • Gorochov G; Service de Médecine Interne 2, Institut E3M, Assistance Publique Hôpitaux de Paris (AP-HP), Hôpital Pitié-Salpêtrière, Paris, France.
  • Martinez-Caceres E; Sorbonne Université, Inserm, Centre d'Immunologie et des Maladies Infectieuses, Cimi-Paris, Paris, France.
  • Sauce D; Service de Médecine Interne 2, Institut E3M, Assistance Publique Hôpitaux de Paris (AP-HP), Hôpital Pitié-Salpêtrière, Paris, France.
Front Cell Infect Microbiol ; 11: 709893, 2021.
Article in English | MEDLINE | ID: covidwho-1403459
ABSTRACT
Highlights Innate immune activation during Covid-19 infection is associated with pernicious clinical outcome.

Background:

Coronavirus disease 2019 (Covid-19) is a worldwide threat that has already caused more than 3 000 000 deaths. It is characterized by different patterns of disease evolution depending on host factors among which old-age and pre-existing comorbidities play a detrimental role. Previous coronavirus epidemics, notably SARS-CoV, were associated with increased serum neopterin levels, which can be interpreted as a sign of acute innate immunity in response to viral infection. Here we hypothesize that neopterin may serve as a biomarker of SARS-CoV-2 viral infection and Covid-19 disease severity.

Methods:

We measured neopterin blood levels by ELISA. Seric concentration was quantified from 256 healthy donors and 374 Covid-19 patients at hospital admission. Enrolled Covid-19 patients were all symptomatic and displayed a large spectrum of comorbidities. Patients were followed until disease resolution or death.

Results:

Severe and critically ill SARS-CoV-2 infected patients were characterized by a profound exacerbation of immune activation characterized by elevated neopterin blood levels. Systemic neopterin levels above 19nM stratified healthy individuals from Covid-19 patients with 87% specificity and 100% sensitivity. Moreover, systemic neopterin levels above 53nM differentiated non-survivors from survivors with 64% specificity and 100% sensitivity.

Conclusion:

We propose that neopterin concentration measured at arrival to hospital is a hallmark of severe Covid-19 and identifies a high-risk population of pernicious clinical outcome with a need for special medical care.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Neopterin / COVID-19 Type of study: Prognostic study / Risk factors Limits: Humans Language: English Journal: Front Cell Infect Microbiol Year: 2021 Document Type: Article Affiliation country: Fcimb.2021.709893

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Neopterin / COVID-19 Type of study: Prognostic study / Risk factors Limits: Humans Language: English Journal: Front Cell Infect Microbiol Year: 2021 Document Type: Article Affiliation country: Fcimb.2021.709893