Your browser doesn't support javascript.
A Multicenter Cohort Study of Indian Centers on Reoccurring SARS-CoV-2 Infections in Kidney Transplant Recipients.
Kute, Vivek B; Hegde, Umapati; Das, Pratik; Sharma, Ashish; Bahadur, Madan M; Sil, Keshab; Guleria, Sandeep; Varma, Prem P; Jamale, Tukaram; Meshram, Hari Shankar.
  • Kute VB; From the Department of Nephrology, Institute of Kidney Diseases and Research Center, Dr. H. L. Trivedi Institute of Transplantation Sciences, Ahmedabad, India.
Exp Clin Transplant ; 19(10): 1023-1031, 2021 10.
Article in English | MEDLINE | ID: covidwho-1404032
ABSTRACT

OBJECTIVES:

There is scarcity of data on reoccurrence of SARS-CoV-2 infections in kidney transplant recipients. MATERIALS AND

METHODS:

We conducted a retrospective multicenter cohort study and identified 13 kidney transplant recipients (10 living and 3 deceased donors) with recurrent COVID-19, and here we report demographics, immunosuppression regimens, clinical profiles, treatments, and outcomes.

RESULTS:

COVID-19 second infection rate was 0.9% (13/1350) in kidney transplant recipients with a median age of 46 years; median time interval from transplant to first episode of COVID-19 diagnosis was 9.2 months (interquartile range, 2.2-46.5 months). The most common comorbidities were hypertension (84%) and diabetes (23%). Fever was significantly less common with recurrent COVID-19. COVID-19 severity ranged from asymptomatic (23%), mild (31%), and moderate (46%) during the first infection and asymptomatic (8%), mild (46%), and severe (46%) in the second infection. All 6 kidney transplant recipients with severe second infections died. The median interval between the 2 episodes based upon reverse transcriptase polymerase chain reaction COVID-19-positive tests was 135 days (interquartile range, 71-274 days) without symptoms. Statistically significant risk factors for mortality were dyspnea (P = .04), disease severity (P = .004), allograft dysfunction (P < .05), higher levels of neutrophil-to-lymphocyte ratio (P = .05), and intensive care unit/ventilator requirement (P = .004). Although our limited resources did not allow for molecular diagnostics and typing, we suggest that these second episodes were reinfections with SARS-CoV-2.

CONCLUSIONS:

To our knowledge, this is the largest study of kidney transplant recipients with reoccurring SARS-CoV-2 infection, and we observed 46% mortality.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Kidney Transplantation / COVID-19 Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Limits: Child, preschool / Humans / Infant Language: English Journal: Exp Clin Transplant Journal subject: Transplantation Year: 2021 Document Type: Article Affiliation country: Ect.2021.0284

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Kidney Transplantation / COVID-19 Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Limits: Child, preschool / Humans / Infant Language: English Journal: Exp Clin Transplant Journal subject: Transplantation Year: 2021 Document Type: Article Affiliation country: Ect.2021.0284