The protective effect of previous COVID-19 infection in a high-prevalence hospital setting.
Clin Med (Lond)
; 21(5): e470-e474, 2021 09.
Article
in English
| MEDLINE | ID: covidwho-1404072
ABSTRACT
OBJECTIVE:
To assess the protective effect of previous COVID-19 infection for healthcare workers in a high-prevalence setting.METHOD:
The COVID-19 antibody and PCR results of 538 healthcare workers on wards with COVID-19 outbreaks from 1 March 2020 to 31 July 2020 were evaluated. Infection rates of the 'previously infected' and 'no evidence of previous infection' groups were compared during second-wave outbreaks between 29 September 2020 and 20 November 2020.RESULTS:
One out of 115 individuals previously infected developed infection compared with 104 out of 423 individuals with no evidence of previous infection. Attack rates in staff previously infected was reduced significantly from 24.59% to 0.87% (odds ratio 0.027, 95% CI 0.004-0.195, p<0.001) when compared to the 'no evidence of previous infection' group with the same exposure risk.CONCLUSION:
Prior SARS-CoV-2 infection offers significant protection against reinfection and this protection lasts 4 months for the majority of individuals.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
COVID-19
Type of study:
Experimental Studies
/
Observational study
/
Prognostic study
/
Randomized controlled trials
Limits:
Humans
Language:
English
Journal:
Clin Med (Lond)
Year:
2021
Document Type:
Article
Affiliation country:
Clinmed.2021-0225
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