Prolonged SARS-CoV-2 Viral Shedding in Patients with COVID-19 was Associated with Delayed Initiation of Arbidol Treatment and Consulting Doctor Later: A Retrospective Cohort Study.
Curr Med Sci
; 41(6): 1096-1104, 2021 Dec.
Article
in English
| MEDLINE | ID: covidwho-1404664
ABSTRACT
OBJECTIVE:
To study data about SARS-CoV-2 virus shedding and clarify the risk factors for prolonged virus shedding.METHODS:
Data were retrospectively collected from adults hospitalized with laboratory-confirmed coronavirus disease-19 (COVID-19) in Wuhan Union Hospital. We compared clinical features among patients with prolonged (a positive SARS-CoV-2 RNA on day 23 after illness onset) and short virus shedding and evaluated risk factors associated with prolonged virus shedding by multivariate regression analysis.RESULTS:
Among 238 patients, the median age was 55.5 years, 57.1% were female, 92.9% (221/238) were administered with arbidol, 58.4% (139/238) were given arbidol in combination with interferon. The median duration of SARS-CoV-2 virus shedding was 23 days (IQR, 17.8-30 days) with a longest one of 51 days. The patients with prolonged virus shedding had higher value of D-dimer (P=0.002), IL-6 (P<0.001), CRP (P=0.005) and more lobes lung lesion (P=0.014) on admission, as well as older age (P=0.017) and more patients with hypertension (P=0.044) than in those the virus shedding less than 23 days. Multivariate regression analysis revealed that prolonged viral shedding was significantly associated with initiation arbidol >8 days after symptom onset [OR 2.447, 95% CI (1.351-4.431)], ≥3 days from onset of symptoms to first medical visitation [OR 1.880, 95% CI (1.035-3.416)], illness onset before Jan. 31, 2020 [OR 3.289, 95% CI (1.474-7.337)]. Arbidol in combination with interferon was also significantly associated with shorter virus shedding [OR 0.363, 95% CI (0.191-0.690)].CONCLUSION:
Duration of SARS-CoV-2 virus shedding was long. Early initiation of arbidol and arbidol in combination with interferon as well as consulting doctor timely after illness onset were helpful for SARS-CoV-2 clearance.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Antiviral Agents
/
Virus Shedding
/
SARS-CoV-2
/
COVID-19
/
COVID-19 Drug Treatment
/
Indoles
Type of study:
Cohort study
/
Experimental Studies
/
Observational study
/
Prognostic study
Topics:
Long Covid
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Asia
Language:
English
Journal:
Curr Med Sci
Year:
2021
Document Type:
Article
Affiliation country:
S11596-021-2434-y
Similar
MEDLINE
...
LILACS
LIS