Inflammasome Activation in Children With Kawasaki Disease and Multisystem Inflammatory Syndrome.

Wang, Wei-Ting; He, Ming; Shimizu, Chisato; Croker, Ben A; Hoffman, Hal M; Tremoulet, Adriana H; Burns, Jane C; Shyy, John Y-J

Wang, Wei-Ting; He, Ming; Shimizu, Chisato; Croker, Ben A; Hoffman, Hal M; Tremoulet, Adriana H; Burns, Jane C; Shyy, John Y-J.

Wang WT; Division of Cardiology, Department of Medicine (W.-T.W., M.H., J.Y.-J.S.), University of California, San Diego, La Jolla.
He M; Division of Cardiology, Department of Medicine (W.-T.W., M.H., J.Y.-J.S.), University of California, San Diego, La Jolla.
Shimizu C; Department of Pediatrics (C.S., B.A.C., H.M.H., A.H.T., J.C.B.), University of California, San Diego, La Jolla.
Croker BA; Department of Pediatrics (C.S., B.A.C., H.M.H., A.H.T., J.C.B.), University of California, San Diego, La Jolla.
Hoffman HM; Department of Pediatrics (C.S., B.A.C., H.M.H., A.H.T., J.C.B.), University of California, San Diego, La Jolla.
Tremoulet AH; Rady Children's Hospital, San Diego, CA (H.M.H., A.H.T., J.C.B.).
Burns JC; Department of Pediatrics (C.S., B.A.C., H.M.H., A.H.T., J.C.B.), University of California, San Diego, La Jolla.
Shyy JY; Rady Children's Hospital, San Diego, CA (H.M.H., A.H.T., J.C.B.).

Arterioscler Thromb Vasc Biol ; 41(9): 2509-2511, 2021 09.

Article in English | MEDLINE | ID: covidwho-1405256

ABSTRACT

ABSTRACT

[Figure see text].

Subject(s)

COVID-19/immunology; Granulocytes/immunology; Inflammasomes/immunology; Inflammation Mediators/immunology; Mucocutaneous Lymph Node Syndrome/immunology; NLR Family, Pyrin Domain-Containing 3 Protein/immunology; Neutrophils/immunology; Systemic Inflammatory Response Syndrome/immunology; Adaptor Proteins, Signal Transducing/blood; Adaptor Proteins, Signal Transducing/genetics; COVID-19/blood; COVID-19/genetics; Caspase 1/blood; Caspase 1/genetics; Caspases, Initiator/blood; Caspases, Initiator/genetics; Gene Expression Profiling; Granulocytes/metabolism; Humans; Inflammasomes/genetics; Inflammasomes/metabolism; Inflammation Mediators/blood; Interleukin-1beta/blood; Interleukin-1beta/genetics; Mucocutaneous Lymph Node Syndrome/blood; Mucocutaneous Lymph Node Syndrome/genetics; NLR Family, Pyrin Domain-Containing 3 Protein/genetics; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism; Neutrophils/metabolism; Systemic Inflammatory Response Syndrome/blood; Systemic Inflammatory Response Syndrome/genetics; Transcriptome

Keywords

Kawasaki disease; MIS-C; TIFA; caspase; inflammasome

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Systemic Inflammatory Response Syndrome / Inflammation Mediators / Inflammasomes / NLR Family, Pyrin Domain-Containing 3 Protein / COVID-19 / Granulocytes / Mucocutaneous Lymph Node Syndrome / Neutrophils Limits: Humans Language: English Journal: Arterioscler Thromb Vasc Biol Journal subject: Vascular Diseases Year: 2021 Document Type: Article

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