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Can we trust in Sars-CoV-2 rapid antigen testing? Preliminary results from a paediatric cohort in the emergency department.
Denina, Marco; Giannone, Virginia; Curtoni, Antonio; Zanotto, Elisa; Garazzino, Silvia; Urbino, Antonio Francesco; Bondone, Claudia.
  • Denina M; Department of Pediatric Emergency, Regina Margherita Children's Hospital, Turin, Italy. marco.denina@gmail.com.
  • Giannone V; Department of Pediatrics, Infectious Diseases Unit, University of Turin, Regina Margherita Children's Hospital, Turin, Italy. marco.denina@gmail.com.
  • Curtoni A; Department of Pediatrics and Public Health, University of Turin, Regina Margherita Children's Hospital, Turin, Italy.
  • Zanotto E; Department of Public Health and Pediatrics, Microbiology and Virology Unit, Molinette Hospital, University of Turin, Città della salute e della Scienza, Turin, Italy.
  • Garazzino S; Department of Public Health and Pediatrics, Microbiology and Virology Unit, Molinette Hospital, University of Turin, Città della salute e della Scienza, Turin, Italy.
  • Urbino AF; Department of Pediatrics, Infectious Diseases Unit, University of Turin, Regina Margherita Children's Hospital, Turin, Italy.
  • Bondone C; Department of Pediatric Emergency, Regina Margherita Children's Hospital, Turin, Italy.
Ir J Med Sci ; 191(4): 1767-1770, 2022 Aug.
Article in English | MEDLINE | ID: covidwho-2256909
ABSTRACT

BACKGROUND:

Rapid identification of Covid-19 in the paediatric emergency department is critical; Antigen tests are fast but poorly investigated in children.

AIMS:

To investigate Sars-CoV-2 antigen rapid test in children.

METHODS:

We compare the performance of LumiraDx with molecular tests in a paediatric emergency department.

RESULTS:

A retrospective cohort of 191 patients with AT and PCR tests performed in the same episode was analysed; 16% resulted positive for Sars-CoV-2. Using the PCR test as the gold standard, we calculated antigen testing overall sensitivity of 94.1%, specificity of 91.9%, and NPV of 99.4%. Only one false-negative test was found.

CONCLUSIONS:

AT may be helpful in the initial screening of patients at PED.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Limits: Child / Humans Language: English Journal: Ir J Med Sci Year: 2022 Document Type: Article Affiliation country: S11845-021-02776-z

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Limits: Child / Humans Language: English Journal: Ir J Med Sci Year: 2022 Document Type: Article Affiliation country: S11845-021-02776-z