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ACE2 correlated with immune infiltration serves as a prognostic biomarker in endometrial carcinoma and renal papillary cell carcinoma: implication for COVID-19.
Yang, Jing; Li, Hongxia; Hu, Shengda; Zhou, Yafeng.
  • Yang J; Department of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
  • Li H; Department of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
  • Hu S; Department of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
  • Zhou Y; Department of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Aging (Albany NY) ; 12(8): 6518-6535, 2020 Apr 27.
Article in English | MEDLINE | ID: covidwho-140657
Semantic information from SemMedBD (by NLM)
1. angiotensin converting enzyme 2 ASSOCIATED_WITH Renal Cell Carcinoma
Subject
angiotensin converting enzyme 2
Predicate
ASSOCIATED_WITH
Object
Renal Cell Carcinoma
2. angiotensin converting enzyme 2 ASSOCIATED_WITH Endometrial Carcinoma
Subject
angiotensin converting enzyme 2
Predicate
ASSOCIATED_WITH
Object
Endometrial Carcinoma
3. angiotensin converting enzyme 2 INTERACTS_WITH B-Lymphocytes
Subject
angiotensin converting enzyme 2
Predicate
INTERACTS_WITH
Object
B-Lymphocytes
4. angiotensin converting enzyme 2 INTERACTS_WITH neutrophil
Subject
angiotensin converting enzyme 2
Predicate
INTERACTS_WITH
Object
neutrophil
5. angiotensin converting enzyme 2 INTERACTS_WITH macrophage
Subject
angiotensin converting enzyme 2
Predicate
INTERACTS_WITH
Object
macrophage
6. Immune Cell LOCATION_OF Subgroup A Nepoviruses
Subject
Immune Cell
Predicate
LOCATION_OF
Object
Subgroup A Nepoviruses
7. Subgroup A Nepoviruses LOCATION_OF angiotensin converting enzyme 2
Subject
Subgroup A Nepoviruses
Predicate
LOCATION_OF
Object
angiotensin converting enzyme 2
8. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
9. Severe Acute Respiratory Syndrome PROCESS_OF Patients
Subject
Severe Acute Respiratory Syndrome
Predicate
PROCESS_OF
Object
Patients
10. angiotensin converting enzyme 2 ASSOCIATED_WITH Renal Cell Carcinoma
Subject
angiotensin converting enzyme 2
Predicate
ASSOCIATED_WITH
Object
Renal Cell Carcinoma
11. angiotensin converting enzyme 2 ASSOCIATED_WITH Endometrial Carcinoma
Subject
angiotensin converting enzyme 2
Predicate
ASSOCIATED_WITH
Object
Endometrial Carcinoma
12. angiotensin converting enzyme 2 INTERACTS_WITH B-Lymphocytes
Subject
angiotensin converting enzyme 2
Predicate
INTERACTS_WITH
Object
B-Lymphocytes
13. angiotensin converting enzyme 2 INTERACTS_WITH neutrophil
Subject
angiotensin converting enzyme 2
Predicate
INTERACTS_WITH
Object
neutrophil
14. angiotensin converting enzyme 2 INTERACTS_WITH macrophage
Subject
angiotensin converting enzyme 2
Predicate
INTERACTS_WITH
Object
macrophage
15. Immune Cell LOCATION_OF Subgroup A Nepoviruses
Subject
Immune Cell
Predicate
LOCATION_OF
Object
Subgroup A Nepoviruses
16. Subgroup A Nepoviruses LOCATION_OF angiotensin converting enzyme 2
Subject
Subgroup A Nepoviruses
Predicate
LOCATION_OF
Object
angiotensin converting enzyme 2
17. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
18. Severe Acute Respiratory Syndrome PROCESS_OF Patients
Subject
Severe Acute Respiratory Syndrome
Predicate
PROCESS_OF
Object
Patients
ABSTRACT
Angiotensin-converting enzyme 2 (ACE2) is a member of the renin-angiotension system, however, the correlation between ACE2 and prognosis in UCEC (Uterine Corpus Endometrial Carcinoma) and KIRP (Kidney Renal Papillary Cell Carcinoma) is not clear. We analyzed the expression levels of ACE2 in the Oncomine and TIMER databases, the correlation between ACE2 and overall survival in the PrognoScan, GEPIA and Kaplan-Meier plotter databases. The correlation between ACE2 and immune infiltration level and the type markers of immune cells was investigated in TIMER database. A prognosis analysis based on the expression levels of ACE2 was further performed in related immune cells subgroup. The ACE2 promoter methylation profile was tested in the UALCAN database. In addition, we used GSE30589 and GSE52920 databases to elucidate the changes of ACE2 expression in vivo and in vitro after SARS-CoV infection. ACE2 was elevated in UCEC and KIRP, and high ACE2 had a favorable prognosis. The expression of ACE2 was positively correlated with the level of immune infiltration of macrophage in KIRP, B cell, CD4+T cell, neutrophil and dendritic cell immune infiltration levels in UCEC. ACE2 was significantly positively correlated with the type markers of B cells and neutrophils, macrophages in UCEC, while ACE2 in KIRP was positively correlated with the type markers of macrophages. High ACE2 expression level had a favorable prognosis in different enriched immune cells subgroups in UCEC and KIRP. And the promoter methylation levels of ACE2 in UCEC and KIRP were significantly reduced. What's more, we found that the expression of ACE2 decreased in vivo and in vitro after SARS-CoV infection. In conclusion, ACE2 expression increased significantly in UCEC and KIRP, elevated ACE2 was positively correlated with immune infiltration and prognosis. Moreover, tumor tissues may be more susceptible to SARS-CoV-2 infection in COVID-19 patients with UCEC and KIRP, which may worsen the prognosis.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Pneumonia, Viral / Carcinoma, Renal Cell / Endometrial Neoplasms / Coronavirus Infections / Peptidyl-Dipeptidase A / Pandemics / Betacoronavirus / Immunity, Cellular / Kidney Neoplasms Subject: Pneumonia, Viral / Carcinoma, Renal Cell / Endometrial Neoplasms / Coronavirus Infections / Peptidyl-Dipeptidase A / Pandemics / Betacoronavirus / Immunity, Cellular / Kidney Neoplasms Type of study: Prognostic study Language: English Journal: Aging (Albany NY) Clinical aspect: Prognosis Year: 2020

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Pneumonia, Viral / Carcinoma, Renal Cell / Endometrial Neoplasms / Coronavirus Infections / Peptidyl-Dipeptidase A / Pandemics / Betacoronavirus / Immunity, Cellular / Kidney Neoplasms Subject: Pneumonia, Viral / Carcinoma, Renal Cell / Endometrial Neoplasms / Coronavirus Infections / Peptidyl-Dipeptidase A / Pandemics / Betacoronavirus / Immunity, Cellular / Kidney Neoplasms Type of study: Prognostic study Language: English Journal: Aging (Albany NY) Clinical aspect: Prognosis Year: 2020
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