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Further Findings Concerning Endothelial Damage in COVID-19 Patients.
Gelzo, Monica; Cacciapuoti, Sara; Pinchera, Biagio; De Rosa, Annunziata; Cernera, Gustavo; Scialò, Filippo; Comegna, Marika; Mormile, Mauro; Fabbrocini, Gabriella; Parrella, Roberto; Corso, Gaetano; Gentile, Ivan; Castaldo, Giuseppe.
  • Gelzo M; CEINGE-Biotecnologie Avanzate, scarl, 80145 Naples, Italy.
  • Cacciapuoti S; Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università di Napoli Federico II, 80131 Naples, Italy.
  • Pinchera B; Dipartimento di Medicina Clinica e Chirurgia, Università di Napoli Federico II, 80131 Naples, Italy.
  • De Rosa A; Dipartimento di Medicina Clinica e Chirurgia, Università di Napoli Federico II, 80131 Naples, Italy.
  • Cernera G; Dipartimento di Malattie Infettive e Emergenze Infettive, Divisione di Malattie Infettive Respiratorie, Ospedale Cotugno, AORN dei Colli, 80131 Naples, Italy.
  • Scialò F; CEINGE-Biotecnologie Avanzate, scarl, 80145 Naples, Italy.
  • Comegna M; Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università di Napoli Federico II, 80131 Naples, Italy.
  • Mormile M; CEINGE-Biotecnologie Avanzate, scarl, 80145 Naples, Italy.
  • Fabbrocini G; Dipartimento di Medicina Traslazionale, Università della Campania L. Vanvitelli, 80131 Naples, Italy.
  • Parrella R; CEINGE-Biotecnologie Avanzate, scarl, 80145 Naples, Italy.
  • Corso G; Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università di Napoli Federico II, 80131 Naples, Italy.
  • Gentile I; Dipartimento di Medicina Clinica e Chirurgia, Università di Napoli Federico II, 80131 Naples, Italy.
  • Castaldo G; Dipartimento di Medicina Clinica e Chirurgia, Università di Napoli Federico II, 80131 Naples, Italy.
Biomolecules ; 11(9)2021 09 16.
Article in English | MEDLINE | ID: covidwho-1408458
ABSTRACT
Systemic vascular damage with micro/macro-thrombosis is a typical feature of severe COVID-19. However, the pathogenesis of this damage and its predictive biomarkers remain poorly defined. For this reason, in this study, serum monocyte chemotactic protein (MCP)-2 and P- and E-selectin levels were analyzed in 204 patients with COVID-19. Serum MCP-2 and P-selectin were significantly higher in hospitalized patients compared with asymptomatic patients. Furthermore, MCP-2 increased with the WHO stage in hospitalized patients. After 1 week of hospitalization, MCP-2 levels were significantly reduced, while P-selectin increased in patients in WHO stage 3 and decreased in patients in WHO stages 5-7. Serum E-selectin was not significantly different between asymptomatic and hospitalized patients. The lower MCP-2 levels after 1 week suggest that endothelial damage triggered by monocytes occurs early in COVID-19 disease progression. MCP-2 may also predict COVID-19 severity. The increase in P-selectin levels, which further increased in mild patients and reduced in severe patients after 1 week of hospitalization, suggests that the inactive form of the protein produced by the cleavage of the active protein from the platelet membrane is present. This may be used to identify a subset of patients that would benefit from targeted therapies. The unchanged levels of E-selectin in these patients suggest that endothelial damage is less relevant.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Endothelium, Vascular / P-Selectin / E-Selectin / Chemokine CCL8 / SARS-CoV-2 / COVID-19 Type of study: Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Year: 2021 Document Type: Article Affiliation country: Biom11091368

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Endothelium, Vascular / P-Selectin / E-Selectin / Chemokine CCL8 / SARS-CoV-2 / COVID-19 Type of study: Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Year: 2021 Document Type: Article Affiliation country: Biom11091368