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Clinical presentation, outcomes and factors associated with mortality: A prospective study from three COVID-19 referral care centres in West Africa.
Jaspard, Marie; Sow, Mamadou Saliou; Juchet, Sylvain; Dienderé, Eric; Serra, Beatrice; Kojan, Richard; Sivahera, Billy; Martin, Caroline; Kinda, Moumouni; Lang, Hans-Joerg; Bangaly Sako, Fodé; Amara Traoré, Fodé; Koumbem, Eudoxie; Tinto, Halidou; Sanou, Adama; Sondo, Apoline; Kaboré, Flavien; Donamou, Joseph; Guilavogui, Jean-Paul-Yassa; Velardo, Fanny; Bicaba, Brice; Marcy, Olivier; Augier, Augustin; Sayadi, Sani; Poda, Armel; Keita, Sakoba; Anglaret, Xavier; Malvy, Denis.
  • Jaspard M; The Alliance for International Medical Action (ALIMA), Dakar, Senegal; Inserm 1219, Univ. Bordeaux, IRD, Bordeaux, France.
  • Sow MS; Service des Maladies Infectieuses, Hôpital National Donka, Conakry, Guinea.
  • Juchet S; The Alliance for International Medical Action (ALIMA), Dakar, Senegal; Inserm 1219, Univ. Bordeaux, IRD, Bordeaux, France.
  • Dienderé E; Service de Médecine interne - Maladies Infectieuses, CHU de Bogodogo, Ouagadougou, Burkina Faso.
  • Serra B; The Alliance for International Medical Action (ALIMA), Dakar, Senegal; Inserm 1219, Univ. Bordeaux, IRD, Bordeaux, France.
  • Kojan R; The Alliance for International Medical Action (ALIMA), Dakar, Senegal.
  • Sivahera B; The Alliance for International Medical Action (ALIMA), Dakar, Senegal.
  • Martin C; The Alliance for International Medical Action (ALIMA), Dakar, Senegal.
  • Kinda M; The Alliance for International Medical Action (ALIMA), Dakar, Senegal.
  • Lang HJ; The Alliance for International Medical Action (ALIMA), Dakar, Senegal.
  • Bangaly Sako F; Service des Maladies Infectieuses, Hôpital National Donka, Conakry, Guinea.
  • Amara Traoré F; Service des Maladies Infectieuses, Hôpital National Donka, Conakry, Guinea.
  • Koumbem E; The Alliance for International Medical Action (ALIMA), Dakar, Senegal.
  • Tinto H; Clinical Research Unit of Nanoro, National Center for Scientific and Technological Research, Ouagadougou, Burkina Faso.
  • Sanou A; Direction des services médicaux et médicotechniques du Centre Hospitalier Universitaire de Tengandogo, Ouagadougou, Burkina Faso.
  • Sondo A; Service des Maladies Infectieuses et Tropicales, Centre Hospitalier Universitaire de Yalgado Ouedraogo, Ouagadougou, Burkina Faso.
  • Kaboré F; Service d'anesthésie réanimation, Centre Hospitalier Universitaire de Tengandogo, Ouagadougou, Burkina Faso.
  • Donamou J; Service d'anesthésie et de réanimation, Hôpital National Donka, Conakry, Guinea.
  • Guilavogui JP; The Alliance for International Medical Action (ALIMA), Dakar, Senegal.
  • Velardo F; Inserm 1219, Univ. Bordeaux, IRD, Bordeaux, France.
  • Bicaba B; Centre des Opérations et Réponses aux Urgences Sanitaires du Burkina Faso, Ouagadougou, Burkina Faso.
  • Marcy O; Inserm 1219, Univ. Bordeaux, IRD, Bordeaux, France.
  • Augier A; The Alliance for International Medical Action (ALIMA), Dakar, Senegal.
  • Sayadi S; The Alliance for International Medical Action (ALIMA), Dakar, Senegal.
  • Poda A; Institut National des Sciences de la Santé (INSSA), Université Nazi Boni, Bobo-Dioulasso, Burkina Faso.
  • Keita S; Agence Nationale de Sécurité Sanitaire (ANSS), Conakry, Guinea.
  • Anglaret X; The Alliance for International Medical Action (ALIMA), Dakar, Senegal; Inserm 1219, Univ. Bordeaux, IRD, Bordeaux, France.
  • Malvy D; Inserm 1219, Univ. Bordeaux, IRD, Bordeaux, France; Department of Infectious Diseases and Tropical Medicine, CHU de Bordeaux, Hôpital Pellegrin, Bordeaux, France. Electronic address: denis.malvy@chu-bordeaux.fr.
Int J Infect Dis ; 108: 45-52, 2021 Jul.
Article in English | MEDLINE | ID: covidwho-1409643
Semantic information from SemMedBD (by NLM)
1. Cessation of life PROCESS_OF Male population group
Subject
Cessation of life
Predicate
PROCESS_OF
Object
Male population group
2. Cessation of life PROCESS_OF Male population group
Subject
Cessation of life
Predicate
PROCESS_OF
Object
Male population group
ABSTRACT

OBJECTIVES:

The overall death toll from COVID-19 in Africa is reported to be low but there is little individual-level evidence on the severity of the disease. This study examined the clinical spectrum and outcome of patients monitored in COVID-19 care centres (CCCs) in two West-African countries.

METHODS:

Burkina Faso and Guinea set up referral CCCs to hospitalise all symptomatic SARS-CoV-2 carriers, regardless of the severity of their symptoms. Data collected from hospitalised patients by November 2020 are presented.

RESULT:

A total of 1,805 patients (64% men, median age 41 years) were admitted with COVID-19. Symptoms lasted for a median of 7 days (IQR 4-11). During hospitalisation, 443 (25%) had a SpO2 < 94% at least once, 237 (13%) received oxygen and 266 (15%) took corticosteroids. Mortality was 5% overall, and 1%, 5% and 14% in patients aged <40, 40-59 and ≥60 years, respectively. In multivariable analysis, the risk of death was higher in men (aOR 2.0, 95% CI 1.1; 3.6), people aged ≥60 years (aOR 2.9, 95% CI 1.7; 4.8) and those with chronic hypertension (aOR 2.1, 95% CI 1.2; 3.4).

CONCLUSION:

COVID-19 is as severe in Africa as elsewhere, and there must be more vigilance for common risk factors such as older age and hypertension.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: COVID-19 Subject: COVID-19 Type of study: Observational study / Risk factors Language: English Journal: Int J Infect Dis Clinical aspect: Etiology Year: 2021

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: COVID-19 Subject: COVID-19 Type of study: Observational study / Risk factors Language: English Journal: Int J Infect Dis Clinical aspect: Etiology Year: 2021
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