A Proposed Insight into the Anti-viral Potential of Silver Nanoparticles against Novel Coronavirus Disease (COVID-19)
Journal of Pharmaceutical Research International
; 33(41B):79-93, 2021.
Article
in English
| Web of Science | ID: covidwho-1410099
ABSTRACT
This article presents a proposed insight into the anti-viral potential of silver nanoparticles against novel coronavirus disease (COVID-19). Possible mechanisms of influence of silver nanoparticles on the coronavirus are considered. Models of nanosilver complexes with spike protein of coronavirus amino acids were constructed using computer quantum-chemical modeling. The values of electron density distribution, highest occupied molecular orbital, lowest unoccupied molecular orbital and electron density distribution gradient for each constructed model are obtained. Analysis of the obtained data showed that the most energy-efficient interaction is the formation of the "tryptophan-nanosilver" complex (E=-5856.83 kkal/mol). According to the results of quantum chemical calculations, the most stable complex is the "cysteine-Ag nanoparticles" complex (Delta E = 0.16 a.u.).
Full text:
Available
Collection:
Databases of international organizations
Database:
Web of Science
Language:
English
Journal:
Journal of Pharmaceutical Research International
Year:
2021
Document Type:
Article
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