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COVID-19 Infection in Children, Infants and Pregnant Subjects: An Overview of Recent Insights and Therapies.
Malcangi, Giuseppina; Inchingolo, Alessio Danilo; Inchingolo, Angelo Michele; Santacroce, Luigi; Marinelli, Grazia; Mancini, Antonio; Vimercati, Luigi; Maggiore, Maria Elena; D'Oria, Maria Teresa; Hazballa, Denisa; Bordea, Ioana Roxana; Xhajanka, Edit; Scarano, Antonio; Farronato, Marco; Tartaglia, Gianluca Martino; Giovanniello, Delia; Nucci, Ludovica; Serpico, Rosario; Sammartino, Gilberto; Capozzi, Loredana; Parisi, Antonio; Di Domenico, Marina; Lorusso, Felice; Contaldo, Maria; Inchingolo, Francesco; Dipalma, Gianna.
  • Malcangi G; Department of Interdisciplinary Medicine, University of Medicine Aldo Moro, 70124 Bari, Italy.
  • Inchingolo AD; Department of Interdisciplinary Medicine, University of Medicine Aldo Moro, 70124 Bari, Italy.
  • Inchingolo AM; Department of Interdisciplinary Medicine, University of Medicine Aldo Moro, 70124 Bari, Italy.
  • Santacroce L; Department of Interdisciplinary Medicine, University of Medicine Aldo Moro, 70124 Bari, Italy.
  • Marinelli G; Department of Interdisciplinary Medicine, University of Medicine Aldo Moro, 70124 Bari, Italy.
  • Mancini A; Department of Interdisciplinary Medicine, University of Medicine Aldo Moro, 70124 Bari, Italy.
  • Vimercati L; Department of Interdisciplinary Medicine, University of Medicine Aldo Moro, 70124 Bari, Italy.
  • Maggiore ME; Department of Interdisciplinary Medicine, University of Medicine Aldo Moro, 70124 Bari, Italy.
  • D'Oria MT; Department of Interdisciplinary Medicine, University of Medicine Aldo Moro, 70124 Bari, Italy.
  • Hazballa D; Department of Medical and Biological Sciences, University of Udine, Via delle Scienze, 206, 33100 Udine, Italy.
  • Bordea IR; Department of Interdisciplinary Medicine, University of Medicine Aldo Moro, 70124 Bari, Italy.
  • Xhajanka E; Kongresi Elbasanit, Rruga: Aqif Pasha, 3001 Elbasan, Albania.
  • Scarano A; Department of Oral Rehabilitation, Faculty of Dentistry, Iuliu Hațieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
  • Farronato M; Department of Dental Prosthesis, Medical University of Tirana, Rruga e Dibrës, U.M.T., 1001 Tirana, Albania.
  • Tartaglia GM; Department of Innovative Technologies in Medicine and Dentistry, University of Chieti-Pescara, 66100 Chieti, Italy.
  • Giovanniello D; UOC Maxillo-Facial Surgery and Dentistry, Department of Biomedical, Surgical and Dental Sciences, School of Dentistry, Fondazione IRCCS Ca Granda, Ospedale Maggiore Policlinico, University of Milan, 20100 Milan, Italy.
  • Nucci L; UOC Maxillo-Facial Surgery and Dentistry, Department of Biomedical, Surgical and Dental Sciences, School of Dentistry, Fondazione IRCCS Ca Granda, Ospedale Maggiore Policlinico, University of Milan, 20100 Milan, Italy.
  • Serpico R; Hospital A.O.S.G. Moscati, Contrada Amoretta, 83100 Avellino, Italy.
  • Sammartino G; Multidisciplinary Department of Medical-Surgical and Dental Specialties, University of Campania Luigi Vanvitelli, Via Luigi de Crecchio, 6, 80138 Naples, Italy.
  • Capozzi L; Multidisciplinary Department of Medical-Surgical and Dental Specialties, University of Campania Luigi Vanvitelli, Via Luigi de Crecchio, 6, 80138 Naples, Italy.
  • Parisi A; Department of Neuroscience, Reproductive Sciences and Dentistry, University of Naples Federico II, 80131 Naples, Italy.
  • Di Domenico M; Istituto Zooprofilattico Sperimentale Della Puglia e Della Basilicata, 71121 Foggia, Italy.
  • Lorusso F; Istituto Zooprofilattico Sperimentale Della Puglia e Della Basilicata, 71121 Foggia, Italy.
  • Contaldo M; Department of Precision Medicine, University of Campania Luigi Vanvitelli, 80138 Naples, Italy.
  • Inchingolo F; Department of Innovative Technologies in Medicine and Dentistry, University of Chieti-Pescara, 66100 Chieti, Italy.
  • Dipalma G; Multidisciplinary Department of Medical-Surgical and Dental Specialties, University of Campania Luigi Vanvitelli, Via Luigi de Crecchio, 6, 80138 Naples, Italy.
Microorganisms ; 9(9)2021 Sep 16.
Article in English | MEDLINE | ID: covidwho-1410333
ABSTRACT

BACKGROUND:

The SARS-CoV-2 pandemic has involved a severe increase of cases worldwide in a wide range of populations. The aim of the present investigation was to evaluate recent insights about COVID-19 infection in children, infants and pregnant subjects.

METHODS:

a literature overview was performed including clinical trials, in vitro studies, reviews and published guidelines regarding the present paper topic. A descriptive synthesis was performed to evaluate recent insights and the effectiveness of therapies for SARS-CoV-2 infection in children, infants and pregnant subjects.

RESULTS:

Insufficient data are available regarding the relationship between COVID-19 and the clinical risk of spontaneous abortion and premature foetus death. A decrease in the incidence of COVID-19 could be correlated to a minor expression of ACE2 in childrens' lungs. At present, a modulation of the dose-effect posology for children and infants is necessary.

CONCLUSIONS:

Pregnant vertical transmission has been hypothesised for SARS-CoV-2 infection. Vaccines are necessary to achieve mass immunity for children and also pregnant subjects.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Observational study / Prognostic study Topics: Vaccines Language: English Year: 2021 Document Type: Article Affiliation country: Microorganisms9091964

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Observational study / Prognostic study Topics: Vaccines Language: English Year: 2021 Document Type: Article Affiliation country: Microorganisms9091964