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New-onset IgG autoantibodies in hospitalized patients with COVID-19.
Chang, Sarah Esther; Feng, Allan; Meng, Wenzhao; Apostolidis, Sokratis A; Mack, Elisabeth; Artandi, Maja; Barman, Linda; Bennett, Kate; Chakraborty, Saborni; Chang, Iris; Cheung, Peggie; Chinthrajah, Sharon; Dhingra, Shaurya; Do, Evan; Finck, Amanda; Gaano, Andrew; Geßner, Reinhard; Giannini, Heather M; Gonzalez, Joyce; Greib, Sarah; Gündisch, Margrit; Hsu, Alex Ren; Kuo, Alex; Manohar, Monali; Mao, Rong; Neeli, Indira; Neubauer, Andreas; Oniyide, Oluwatosin; Powell, Abigail E; Puri, Rajan; Renz, Harald; Schapiro, Jeffrey; Weidenbacher, Payton A; Wittman, Richard; Ahuja, Neera; Chung, Ho-Ryun; Jagannathan, Prasanna; James, Judith A; Kim, Peter S; Meyer, Nuala J; Nadeau, Kari C; Radic, Marko; Robinson, William H; Singh, Upinder; Wang, Taia T; Wherry, E John; Skevaki, Chrysanthi; Luning Prak, Eline T; Utz, Paul J.
  • Chang SE; Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, USA.
  • Feng A; Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, USA.
  • Meng W; Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, USA.
  • Apostolidis SA; Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, USA.
  • Mack E; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Artandi M; Department of Medicine, Division of Rheumatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Barman L; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Bennett K; Department of Hematology, Oncology, Immunology, Philipps University Marburg, Marburg, Germany.
  • Chakraborty S; Department of Medicine, Division of Primary Care and Population Health, Stanford University School of Medicine, Stanford, CA, USA.
  • Chang I; Department of Medicine, Stanford CROWN Clinic, Stanford University School of Medicine, Stanford, CA, USA.
  • Cheung P; Department of Medicine, Division of Primary Care and Population Health, Stanford University School of Medicine, Stanford, CA, USA.
  • Chinthrajah S; Molecular Pathology and Imaging Core, Department of Medicine, Gastroenterology Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Dhingra S; Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Stanford, CA, USA.
  • Do E; Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, USA.
  • Finck A; Department of Medicine, Sean N. Parker Center for Allergy and Asthma Research, Stanford University School of Medicine, Stanford, CA, USA.
  • Gaano A; Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, USA.
  • Geßner R; Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, USA.
  • Giannini HM; Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, USA.
  • Gonzalez J; Department of Medicine, Sean N. Parker Center for Allergy and Asthma Research, Stanford University School of Medicine, Stanford, CA, USA.
  • Greib S; Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, USA.
  • Gündisch M; Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, USA.
  • Hsu AR; Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, USA.
  • Kuo A; Department of Medicine, Sean N. Parker Center for Allergy and Asthma Research, Stanford University School of Medicine, Stanford, CA, USA.
  • Manohar M; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Mao R; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Neeli I; Institute of Laboratory Medicine, Philipps University Marburg, Marburg, Germany.
  • Neubauer A; Department of Microbiology, Immunology and Biochemistry, The University of Tennessee Health Science Center, Memphis, TN, USA.
  • Oniyide O; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Powell AE; Institute of Laboratory Medicine, Philipps University Marburg, Marburg, Germany.
  • Puri R; Institute of Laboratory Medicine, Philipps University Marburg, Marburg, Germany.
  • Renz H; Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, USA.
  • Schapiro J; Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, USA.
  • Weidenbacher PA; Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, USA.
  • Wittman R; Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, USA.
  • Ahuja N; Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, USA.
  • Chung HR; Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Stanford, CA, USA.
  • Jagannathan P; Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, USA.
  • James JA; Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, USA.
  • Kim PS; Department of Microbiology, Immunology and Biochemistry, The University of Tennessee Health Science Center, Memphis, TN, USA.
  • Meyer NJ; Department of Hematology, Oncology, Immunology, Philipps University Marburg, Marburg, Germany.
  • Nadeau KC; Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Radic M; Department of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA.
  • Robinson WH; ChEM-H, Stanford University, Stanford, USA.
  • Singh U; Department of Medicine, Division of Primary Care and Population Health, Stanford University School of Medicine, Stanford, CA, USA.
  • Wang TT; Institute of Laboratory Medicine, Philipps University Marburg, Marburg, Germany.
  • Wherry EJ; Member of the Universities of Giessen and Marburg Lung Center (UGMLC), and the German Center for Lung Research (DZL), Giessen, Germany.
  • Skevaki C; TPMG Regional Reference Laboratory, Kaiser Permanente Northern California, Berkeley, CA, USA.
  • Luning Prak ET; Department of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA.
  • Utz PJ; ChEM-H, Stanford University, Stanford, USA.
Nat Commun ; 12(1): 5417, 2021 09 14.
Article in English | MEDLINE | ID: covidwho-1410404
Preprint
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ABSTRACT
COVID-19 is associated with a wide range of clinical manifestations, including autoimmune features and autoantibody production. Here we develop three protein arrays to measure IgG autoantibodies associated with connective tissue diseases, anti-cytokine antibodies, and anti-viral antibody responses in serum from 147 hospitalized COVID-19 patients. Autoantibodies are identified in approximately 50% of patients but in less than 15% of healthy controls. When present, autoantibodies largely target autoantigens associated with rare disorders such as myositis, systemic sclerosis and overlap syndromes. A subset of autoantibodies targeting traditional autoantigens or cytokines develop de novo following SARS-CoV-2 infection. Autoantibodies track with longitudinal development of IgG antibodies recognizing SARS-CoV-2 structural proteins and a subset of non-structural proteins, but not proteins from influenza, seasonal coronaviruses or other pathogenic viruses. We conclude that SARS-CoV-2 causes development of new-onset IgG autoantibodies in a significant proportion of hospitalized COVID-19 patients and are positively correlated with immune responses to SARS-CoV-2 proteins.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Autoantibodies / Immunoglobulin G / SARS-CoV-2 / COVID-19 Type of study: Controlled clinical trial / Prognostic study Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2021 Document Type: Article Affiliation country: S41467-021-25509-3

Full text: Available Collection: International databases Database: MEDLINE Main subject: Autoantibodies / Immunoglobulin G / SARS-CoV-2 / COVID-19 Type of study: Controlled clinical trial / Prognostic study Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2021 Document Type: Article Affiliation country: S41467-021-25509-3