Oligonucleotide aptamers for pathogen detection and infectious disease control.
Theranostics
; 11(18): 9133-9161, 2021.
Article
in English
| MEDLINE | ID: covidwho-1410987
ABSTRACT
During an epidemic or pandemic, the primary task is to rapidly develop precise diagnostic approaches and effective therapeutics. Oligonucleotide aptamer-based pathogen detection assays and control therapeutics are promising, as aptamers that specifically recognize and block pathogens can be quickly developed and produced through simple chemical synthesis. This work reviews common aptamer-based diagnostic techniques for communicable diseases and summarizes currently available aptamers that target various pathogens, including the SARS-CoV-2 virus. Moreover, this review discusses how oligonucleotide aptamers might be leveraged to control pathogen propagation and improve host immune system responses. This review offers a comprehensive data source to the further develop aptamer-based diagnostics and therapeutics specific for infectious diseases.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Bacteria
/
Viruses
/
Communicable Diseases
/
Molecular Diagnostic Techniques
/
Aptamers, Nucleotide
Type of study:
Diagnostic study
/
Systematic review/Meta Analysis
Limits:
Humans
Language:
English
Journal:
Theranostics
Year:
2021
Document Type:
Article
Affiliation country:
Thno.61804
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