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Molnupiravir Inhibits Replication of the Emerging SARS-CoV-2 Variants of Concern in a Hamster Infection Model.
Abdelnabi, Rana; Foo, Caroline S; De Jonghe, Steven; Maes, Piet; Weynand, Birgit; Neyts, Johan.
  • Abdelnabi R; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium.
  • Foo CS; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium.
  • De Jonghe S; Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium.
  • Maes P; Laboratory of Clinical and Epidemiological Virology, Department of Microbiology, Immunology and Transplantation, Rega Institute, Katholieke Universiteit Leuven, Leuven, Belgium.
  • Weynand B; Zoonotic Infectious Diseases Unit, KU Leuven, Leuven, Belgium.
  • Neyts J; Department of Imaging and Pathology, Division of Translational Cell and Tissue Research, Katholieke Universiteit Leuven, Leuven, Belgium.
J Infect Dis ; 224(5): 749-753, 2021 09 01.
Article in English | MEDLINE | ID: covidwho-1411568
ABSTRACT
The emergence of SARS-CoV-2 variants of concern (VoCs) has exacerbated the COVID-19 pandemic. Currently available monoclonal antibodies and vaccines appear to have reduced efficacy against some of these VoCs. Antivirals targeting conserved proteins of SARS-CoV-2 are unlikely to be affected by mutations arising in VoCs and should therefore be effective against emerging variants. We here investigate the efficacy of molnupiravir, currently in phase 2 clinical trials, in hamsters infected with Wuhan strain or B.1.1.7 and B.1.351 variants. Molnupiravir proved to be effective against infections with each of the variants and therefore may have potential combating current and future emerging VoCs.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Virus Replication / Cytidine / SARS-CoV-2 / COVID-19 Drug Treatment / Hydroxylamines Type of study: Prognostic study Topics: Vaccines / Variants Limits: Animals / Female / Humans Language: English Journal: J Infect Dis Year: 2021 Document Type: Article Affiliation country: Infdis

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Virus Replication / Cytidine / SARS-CoV-2 / COVID-19 Drug Treatment / Hydroxylamines Type of study: Prognostic study Topics: Vaccines / Variants Limits: Animals / Female / Humans Language: English Journal: J Infect Dis Year: 2021 Document Type: Article Affiliation country: Infdis