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Maternal characteristics and pregnancy outcomes of hospitalized pregnant women with SARS-CoV-2 infection in South Africa: An International Network of Obstetric Survey Systems-based cohort study.
Budhram, Samantha; Vannevel, Valerie; Botha, Tanita; Chauke, Lawrence; Bhoora, Shastra; Balie, Gaynor M; Odell, Natalie; Lombaard, Hennie; Wise, Amy; Georgiou, Chrysanthi; Ngxola, Nondumiso; Wynne, Emma; Mbewu, Unati; Mabenge, Mfundo; Phinzi, Sibusiso; Gubu-Ntaba, Nontsikelelo; Goldman, Gareth; Tunkyi, Kay; Prithipal, Sudhir; Naidoo, Keshree; Venkatachalam, Santhi; Moodley, Terence; Mould, Sean; Hlabisa, Mzuvele; Govender, Logie; Maistry, Charlene; Habineza, John P; Israel, Priya; Foolchand, Serantha; Tsibiyane, Nomandla V; Panday, Mala; Soma-Pillay, Priya; Adam, Sumaiya; Molokoane, Felicia; Mojela, Matthew S; van Rensburg, Elizabeth J; Mashamba, Tshililo; Matjila, Mushi; Fawcus, Sue; Osman, Ayesha; Venter, Mareli; Petro, Gregory; Fakier, Ahminah; Langenegger, Eduard; Cluver, Catherine A; Bekker, Adrie; de Waard, Liesl; Stewart, Chantal; Ngene, Nnabuike C; Lunda, Ongombe.
  • Budhram S; Maternal Foetal Medicine Unit, Department of Obstetrics and Gynaecology, Inkosi Albert Luthuli Central Hospital, Durban, South Africa.
  • Vannevel V; Department of Obstetrics and Gynaecology, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.
  • Botha T; Research Centre for Maternal, Fetal, Newborn & Child Health Care Strategies, Cape Town, South Africa.
  • Chauke L; Maternal and Infant Health Care Strategies Unit, South African Medical Research Council (SA MRC), Cape Town, South Africa.
  • Bhoora S; Department of Obstetrics & Gynecology, Kalafong Hospital, University of Pretoria, Pretoria, South Africa.
  • Balie GM; Department of Statistics, Faculty of Natural and Agricultural Sciences, University of Pretoria, Pretoria, South Africa.
  • Odell N; Department of Obstetrics and Gynecology, Charlotte Maxeke Johannesburg Academic Hospital, University of the Witwatersrand, Johannesburg, South Africa.
  • Lombaard H; Department of Obstetrics and Gynecology, Charlotte Maxeke Johannesburg Academic Hospital, University of the Witwatersrand, Johannesburg, South Africa.
  • Wise A; Maternal Critical Care, Baylor College, Houston, Texas, USA.
  • Georgiou C; Department of Obstetrics and Gynecology, Charlotte Maxeke Johannesburg Academic Hospital, University of the Witwatersrand, Johannesburg, South Africa.
  • Ngxola N; Department of Obstetrics and Gynecology, Charlotte Maxeke Johannesburg Academic Hospital, University of the Witwatersrand, Johannesburg, South Africa.
  • Wynne E; Department Obstetrics and Gynaecology, Rahima Moosa Mother and Child Hospital, University of the Witwatersrand, Johannesburg, South Africa.
  • Mbewu U; Department Obstetrics and Gynaecology, Rahima Moosa Mother and Child Hospital, University of the Witwatersrand, Johannesburg, South Africa.
  • Mabenge M; Department Obstetrics and Gynaecology, Rahima Moosa Mother and Child Hospital, University of the Witwatersrand, Johannesburg, South Africa.
  • Phinzi S; Department of Obstetrics and Gynaecology, Frere Hospital, Walter Sisulu University, Mthatha, South Africa.
  • Gubu-Ntaba N; Department of Obstetrics and Gynaecology, Frere Hospital, Walter Sisulu University, Mthatha, South Africa.
  • Goldman G; Department of Obstetrics and Gynaecology, Frere Hospital, Walter Sisulu University, Mthatha, South Africa.
  • Tunkyi K; Department of Obstetrics and Gynecology, Dora Nginza Hospital, Walter Sisulu University, Mthatha, South Africa.
  • Prithipal S; Department of Obstetrics and Gynaecology, Nelson Mandela Academic Hospital, Walter Sisulu University, Mthatha, South Africa.
  • Naidoo K; Department of Obstetrics and Gynaecology, Nelson Mandela Academic Hospital, Walter Sisulu University, Mthatha, South Africa.
  • Venkatachalam S; Department of Obstetrics and Gynaecology, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.
  • Moodley T; Department of Obstetrics and Gynaecology, Addington Hospital, University of Kwazulu Natal, Durban, South Africa.
  • Mould S; Department of Obstetrics and Gynaecology, Addington Hospital, University of Kwazulu Natal, Durban, South Africa.
  • Hlabisa M; Department of Obstetrics and Gynecology, Mahatma Gandhi Memorial Regional Hospital, University of KwaZulu Natal, Durban, South Africa.
  • Govender L; Department of Obstetrics and Gynecology, Mahatma Gandhi Memorial Regional Hospital, University of KwaZulu Natal, Durban, South Africa.
  • Maistry C; Department of Obstetrics and Gynecology, Prince Mshiyeni Memorial Hospital, University of Kwazulu Natal, Durban, South Africa.
  • Habineza JP; Department of Obstetrics and Gynecology, R.K. Khan Hospital, University of Kwazulu Natal, Durban, South Africa.
  • Israel P; Department of Obstetrics and Gynecology, R.K. Khan Hospital, University of Kwazulu Natal, Durban, South Africa.
  • Foolchand S; Department of Obstetrics & Gynecology, Queen Nandi Regional Hospital, University of Kwazulu Natal, Durban, South Africa.
  • Tsibiyane NV; Department of Obstetrics and Gynecology, Port Shepstone Regional Hospital, Port Shepstone, South Africa.
  • Panday M; Department of Obstetrics and Gynecology, Port Shepstone Regional Hospital, Port Shepstone, South Africa.
  • Soma-Pillay P; Department of Obstetrics and Gynecology, Edendale Hospital, Pietermaritzburg, South Africa.
  • Adam S; University of Kwazulu Natal, Durban, South Africa.
  • Molokoane F; Maternal Fetal Unit: Department of Obstetrics and Gynecology, Greys Hospital, University of Kwazulu Natal, Durban, South Africa.
  • Mojela MS; Maternal Fetal Unit: Department of Obstetrics and Gynecology, Greys Hospital, University of Kwazulu Natal, Durban, South Africa.
  • van Rensburg EJ; Department of Obstetrics and Gynaecology, King Dinizulu Hospital Complex, University of Kwazulu Natal, Durban, South Africa.
  • Mashamba T; Research Centre for Maternal, Fetal, Newborn & Child Health Care Strategies, Cape Town, South Africa.
  • Matjila M; Maternal and Infant Health Care Strategies Unit, South African Medical Research Council (SA MRC), Cape Town, South Africa.
  • Fawcus S; Department of Obstetrics and Gynaecology, Steve Biko Academic Hospital, University of Pretoria, Pretoria, South Africa.
  • Osman A; Research Centre for Maternal, Fetal, Newborn & Child Health Care Strategies, Cape Town, South Africa.
  • Venter M; Maternal and Infant Health Care Strategies Unit, South African Medical Research Council (SA MRC), Cape Town, South Africa.
  • Petro G; Department of Obstetrics and Gynaecology, Steve Biko Academic Hospital, University of Pretoria, Pretoria, South Africa.
  • Fakier A; Research Centre for Maternal, Fetal, Newborn & Child Health Care Strategies, Cape Town, South Africa.
  • Langenegger E; Maternal and Infant Health Care Strategies Unit, South African Medical Research Council (SA MRC), Cape Town, South Africa.
  • Cluver CA; Department of Obstetrics & Gynecology, Kalafong Hospital, University of Pretoria, Pretoria, South Africa.
  • Bekker A; Department of Obstetrics & Gynecology, Kalafong Hospital, University of Pretoria, Pretoria, South Africa.
  • de Waard L; Department of Obstetrics & Gynecology, Kalafong Hospital, University of Pretoria, Pretoria, South Africa.
  • Stewart C; Department of Obstetrics and Gynecology, Sefako Makgatho Health Sciences University, Ga-Rankuwa, South Africa.
  • Ngene NC; Department of Obstetrics and Gynecology, Groote Schuur Hospital, Cape Town, South Africa.
  • Lunda O; MRC/UCT Receptor Biology Unit, Division of Medical Biochemistry, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Int J Gynaecol Obstet ; 155(3): 455-465, 2021 Dec.
Article in English | MEDLINE | ID: covidwho-1411905
ABSTRACT

OBJECTIVE:

To describe risk factors and outcomes of pregnant women infected with SARS-CoV-2 admitted to South African healthcare facilities.

METHODS:

A population-based cohort study was conducted utilizing an amended International Obstetric Surveillance System protocol. Data on pregnant women with SARS-CoV-2 infection, hospitalized between April 14, 2020, and November 24, 2020, were analyzed.

RESULTS:

A total of 36 hospitals submitted data on 673 infected hospitalized pregnant women; 217 (32.2%) were admitted for COVID-19 illness and 456 for other indications. There were 39 deaths with a case fatality rate of 6.3% 32 (14.7%) deaths occurred in women admitted for COVID-19 illness compared to 7 (1.8%) in women admitted for other indications. Of the women, 106 (15.9%) required critical care. Maternal tuberculosis, but not HIV co-infection or other co-morbidities, was associated with admission for COVID-19 illness. Rates of cesarean delivery did not differ significantly between women admitted for COVID-19 and those admitted for other indications. There were 179 (35.4%) preterm births, 25 (4.7%) stillbirths, 12 (2.3%) neonatal deaths, and 162 (30.8%) neonatal admissions. Neonatal outcomes did not differ significantly from those of infected women admitted for other indications.

CONCLUSION:

The maternal mortality rate was high among women admitted with SARS-CoV-2 infection and higher in women admitted primarily for COVID-19 illness with tuberculosis being the only co-morbidity associated with admission.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pregnancy Complications, Infectious / Premature Birth / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Limits: Female / Humans / Infant, Newborn / Pregnancy Country/Region as subject: Africa Language: English Journal: Int J Gynaecol Obstet Year: 2021 Document Type: Article Affiliation country: Ijgo.13917

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pregnancy Complications, Infectious / Premature Birth / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Limits: Female / Humans / Infant, Newborn / Pregnancy Country/Region as subject: Africa Language: English Journal: Int J Gynaecol Obstet Year: 2021 Document Type: Article Affiliation country: Ijgo.13917