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Specific detection of memory T-cells in COVID-19 patients using standardized whole-blood Interferon gammarelease assay.
Mouton, William; Compagnon, Christelle; Saker, Kahina; Daniel, Soizic; Djebali, Sophia; Lacoux, Xavier; Pozzetto, Bruno; Oriol, Guy; Laubreton, Daphné; Prieux, Margaux; Fassier, Jean-Baptiste; Guibert, Nicolas; Massardier-Pilonchéry, Amélie; Alfaiate, Dulce; Berthier, Franck; Walzer, Thierry; Marvel, Jacqueline; Brengel-Pesce, Karen; Trouiller-Assant, Sophie.
  • Mouton W; Joint Research Unit Hospices Civils de Lyon-bioMérieux, Civils Hospices of Lyon, Pierre-Bénite, Lyon Sud Hospital, Lyon, France.
  • Compagnon C; CIRI- International Centre for Research in Infectiology (CIRI), INSERM U1111, CNRS UMR5308, ENS de Lyon, Claude Bernard Lyon 1 University, Lyon, France.
  • Saker K; Open Innovation & Partnerships (OIP), bioMérieux S.A., Marcy l'Etoile, France.
  • Daniel S; Joint Research Unit Hospices Civils de Lyon-bioMérieux, Civils Hospices of Lyon, Pierre-Bénite, Lyon Sud Hospital, Lyon, France.
  • Djebali S; Open Innovation & Partnerships (OIP), bioMérieux S.A., Marcy l'Etoile, France.
  • Lacoux X; Joint Research Unit Hospices Civils de Lyon-bioMérieux, Civils Hospices of Lyon, Pierre-Bénite, Lyon Sud Hospital, Lyon, France.
  • Pozzetto B; R&D - Immunoassay, bioMérieux S.A., Marcy l'Etoile, France.
  • Oriol G; CIRI- International Centre for Research in Infectiology (CIRI), INSERM U1111, CNRS UMR5308, ENS de Lyon, Claude Bernard Lyon 1 University, Lyon, France.
  • Laubreton D; R&D - Immunoassay, bioMérieux S.A., Marcy l'Etoile, France.
  • Prieux M; GIMAP EA 3064 (Groupe Immunité des Muqueuses et Agents Pathogènes), Lyon University, Jean Monnet University, Saint-Etienne, France.
  • Fassier JB; Laboratoire des Agents Infectieux et Hygiène, Saint-Etienne Univesity hospital, Saint-Etienne, France.
  • Guibert N; Joint Research Unit Hospices Civils de Lyon-bioMérieux, Civils Hospices of Lyon, Pierre-Bénite, Lyon Sud Hospital, Lyon, France.
  • Massardier-Pilonchéry A; Open Innovation & Partnerships (OIP), bioMérieux S.A., Marcy l'Etoile, France.
  • Alfaiate D; CIRI- International Centre for Research in Infectiology (CIRI), INSERM U1111, CNRS UMR5308, ENS de Lyon, Claude Bernard Lyon 1 University, Lyon, France.
  • Berthier F; CIRI- International Centre for Research in Infectiology (CIRI), INSERM U1111, CNRS UMR5308, ENS de Lyon, Claude Bernard Lyon 1 University, Lyon, France.
  • Walzer T; Lyon University, Ifsttar, UMRESTTE, UMR T_9405, Claude Bernard Lyon 1 University, Lyon, France.
  • Marvel J; Occupational Health and Medicine Department, Civils Hospices of Lyon, Lyon, France.
  • Brengel-Pesce K; Lyon University, Ifsttar, UMRESTTE, UMR T_9405, Claude Bernard Lyon 1 University, Lyon, France.
  • Trouiller-Assant S; Occupational Health and Medicine Department, Civils Hospices of Lyon, Lyon, France.
Eur J Immunol ; 51(12): 3239-3242, 2021 12.
Article in English | MEDLINE | ID: covidwho-1413180
ABSTRACT
Antigen-specific T-cells are essential for protective immunity against SARS-CoV-2. We set up a semi-automated whole-blood Interferon-gamma release assay (WB IGRA) to monitor the T-cell response after stimulation with SARS-CoV-2 peptide pools. We report that the WB IGRA is complementary to serological assays to assess SARS-CoV-2 immunity.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Interferon-gamma / SARS-CoV-2 / COVID-19 / Memory T Cells Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Limits: Adult / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Eur J Immunol Year: 2021 Document Type: Article Affiliation country: Eji.202149296

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Interferon-gamma / SARS-CoV-2 / COVID-19 / Memory T Cells Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Limits: Adult / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Eur J Immunol Year: 2021 Document Type: Article Affiliation country: Eji.202149296