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Extreme immunotherapy: emergency immunology to defeat pandemics.
Nixon, Douglas F; Marín-Hernández, Daniela; Hupert, Nathaniel.
  • Nixon DF; Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, Belfer Research Building, Room 530, 413 E. 69th Street, New York, NY, 10065, USA. dnixon@med.cornell.edu.
  • Marín-Hernández D; Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, Belfer Research Building, Room 530, 413 E. 69th Street, New York, NY, 10065, USA.
  • Hupert N; Department of Population Health Sciences, Weill Cornell Medicine, 402 E. 67th Street, New York, NY, 10065, USA.
Mol Med ; 27(1): 112, 2021 09 16.
Article in English | MEDLINE | ID: covidwho-1413278
ABSTRACT
The ongoing global COVID-19 pandemic has thrown into sharp relief the gap between modern biology's ability to investigate and respond to a novel pathogen and modern medicine's ability to marshal effective front-line interventions to limit its immediate health impact. While we have witnessed the rapid development of innovative vaccines against SARS-CoV-2 using novel molecular platforms, these have yet to alter the pandemic's long-term trajectory in all but a handful of high-income countries. Health workers at the clinical front lines have little more in their clinical armamentarium than was available a century ago-chiefly oxygen and steroids-and yet advances in modern immunology and immunotherapeutics suggest an underuse of extant and effective, if unorthodox, therapies, which we now call "Extreme Immunotherapies for Pandemics (EIPs)."
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pandemics Type of study: Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Mol Med Journal subject: Molecular Biology Year: 2021 Document Type: Article Affiliation country: S10020-021-00366-4

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pandemics Type of study: Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Mol Med Journal subject: Molecular Biology Year: 2021 Document Type: Article Affiliation country: S10020-021-00366-4