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Clinical characteristics and outcomes of critically ill patients with acute COVID-19 with Epstein-Barr virus reactivation.
Xie, Yun; Cao, Song; Dong, Hui; Lv, Hui; Teng, Xiaolei; Zhang, Jiaxiang; Wang, Tao; Zhang, Xiaoyan; Qin, Yun; Chai, Yujing; Yang, Luyu; Liu, Jun; Wang, Ruilan.
  • Xie Y; Critical Care Unit, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 650 New Songjiang Road, Songjiang, Shanghai, 201600, People's Republic of China.
  • Cao S; Critical Care Unit, Wuhan Third Hospital, Wuhan University, Wuhan, China.
  • Dong H; Critical Care Unit, Wuhan Third Hospital, Wuhan University, Wuhan, China.
  • Lv H; Critical Care Unit, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 650 New Songjiang Road, Songjiang, Shanghai, 201600, People's Republic of China.
  • Teng X; Critical Care Unit, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 650 New Songjiang Road, Songjiang, Shanghai, 201600, People's Republic of China.
  • Zhang J; Critical Care Unit, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 650 New Songjiang Road, Songjiang, Shanghai, 201600, People's Republic of China.
  • Wang T; Critical Care Unit, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 650 New Songjiang Road, Songjiang, Shanghai, 201600, People's Republic of China.
  • Zhang X; Critical Care Unit, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 650 New Songjiang Road, Songjiang, Shanghai, 201600, People's Republic of China.
  • Qin Y; Chongming Hospital of the Branch Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Chai Y; Shanghai Yangpu District Mental Health Center, Shanghai, China.
  • Yang L; Critical Care Unit, Wuhan Third Hospital, Wuhan University, Wuhan, China.
  • Liu J; Nephrology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. liujun-sgh@sjtu.edu.cn.
  • Wang R; Critical Care Unit, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 650 New Songjiang Road, Songjiang, Shanghai, 201600, People's Republic of China. wangyusun@hotmail.com.
BMC Infect Dis ; 21(1): 955, 2021 Sep 15.
Article in English | MEDLINE | ID: covidwho-1414111
ABSTRACT

BACKGROUND:

Our goal is to further elucidate the clinical condition and prognosis of patients with severe acute COVID-19 with EBV reactivation.

METHOD:

This is a retrospective single-center study of COVID-19 patients admitted to the intensive care unit of Wuhan No. 3 Hospital (January 31 to March 27, 2020). According to whether Epstein-Barr virus reactivation was detected, the patients were divided into an EBV group and a Non-EBV group. Baseline data were collected including epidemiological, larithmics, clinical and imaging characteristics, and laboratory examination data.

RESULTS:

Of the 128 patients with COVID-19, 17 (13.3%) were infected with Epstein-Barr virus reactivation. In the symptoms,the rate of tachypnoea in the EBV group was apparently higher than that in the Non-EBV group. In lab tests, the lymphocyte and albumin of EBV group decreased more significantly than Non-EBV group, and the D-dimer and serum calcium of EBV group was higher than Non-EBV group. Regarding the infection index, CRP of EBV group was apparently above the Non-EBV group, and no significant difference was found in procalcitonin of the two groups. The incidence of respiratory failure, ARDS, and hypoproteinaemia of EBV group had more incidence than Non-EBV group. The 28-day and 14-day mortality rates of EBV group was significantly higher than that of Non-EBV group.

CONCLUSIONS:

In the COVID-19 patients, patients with EBV reactivation had higher 28-day and 14-day mortality rates and received more immuno-supportive treatment than patients of Non-EBV group.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Epstein-Barr Virus Infections / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Humans Language: English Journal: BMC Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Epstein-Barr Virus Infections / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Humans Language: English Journal: BMC Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article