Genetics of Acute Respiratory Distress Syndrome: Pathways to Precision.
Crit Care Clin
; 37(4): 817-834, 2021 Oct.
Article
in English
| MEDLINE | ID: covidwho-1414516
ABSTRACT
Clinical risk factors alone fail to fully explain acute respiratory distress syndrome (ARDS) risk or ARDS death, suggesting that individual risk factors contribute. The goals of genomic ARDS studies include better mechanistic understanding, identifying dysregulated pathways that may be amenable to pharmacologic targeting, using genomic causal inference techniques to find measurable traits with meaning, and deconvoluting ARDS heterogeneity by proving reproducible subpopulations that may share a unique biology. This article discusses the latest advances in ARDS genomics, provides historical perspective, and highlights some of the ways that the coronavirus disease 2019 (COVID-19) pandemic is accelerating genomic ARDS research.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Respiratory Distress Syndrome
/
COVID-19
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Crit Care Clin
Journal subject:
Critical Care
Year:
2021
Document Type:
Article
Affiliation country:
J.ccc.2021.05.006
Similar
MEDLINE
...
LILACS
LIS