Pericardial Cytokine "Storm" in a COVID-19 Patient: the Confirmation of a Hypothesis.
Inflammation
; 45(1): 1-5, 2022 Feb.
Article
in English
| MEDLINE | ID: covidwho-1415062
ABSTRACT
Novel Coronavirus Disease in most cases produces mild symptoms which resolve after a few days. Some authors hypothesized that SARS-CoV-2 infection could trigger excessive cytokine production leading to a severe multi-organ disease requiring intensive care admission. Respiratory and neurological symptoms are the most frequently reported manifestation of the disease. Indeed, cardiac involvement is reported mostly as a part of a systemic disease. Few isolated cardiac manifestations of COVID-19 infection have been described. We report herein a case of SARS-CoV-2 related severe isolated pericardial involvement requiring ICU admission due to cardiac tamponade needing urgent drainage. Analysis of pericardial fluid from drainage demonstrated a higher cytokine concentration than blood values. Other causes of pericardial disease, such as autoimmunity, bacterial or other than COVID-19 infection, neoplasms or acute myocardial infarction were also evaluated, but all tests confirmed negative results. The suspicion of isolated involvement of the pericardium was therefore demonstrated by the analysis of cytokines which strongly support our hypothesis.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pericardial Effusion
/
Pericardium
/
Cardiac Tamponade
/
Cytokines
/
Pericardial Fluid
/
COVID-19
Type of study:
Case report
/
Experimental Studies
Limits:
Aged
/
Humans
/
Male
Language:
English
Journal:
Inflammation
Year:
2022
Document Type:
Article
Affiliation country:
S10753-021-01563-3
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