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Sero-prevalence of anti-SARS-CoV-2 antibodies among healthcare workers: A multicenter study from Egypt.
El-Sokkary, Rehab H; Daef, Enas; El-Korashi, Lobna A; Khedr, Eman M; Gad, Doaa; Mohamed-Hussein, Aliae; Zayed, Niveen E; Mostafa, Ehab F; Bahgat, Shereen M; Hassany, Sahar M; Amer, Marwa G; El-Mokhtar, Mohamed A; Elantouny, Neveen G; Hassan, Shimaa A; Zarzour, Amro A; Hashem, Maiada K; Amin, Mariam T; Hassan, Hebatallah M.
  • El-Sokkary RH; Medical Microbiology and Immunology Department, Faculty of Medicine, Zagazig University, Egypt. Electronic address: rehab_elsokkary@zu.edu.eg.
  • Daef E; Medical Microbiology and Immunology Department, Faculty of Medicine, Assiut University, Egypt.
  • El-Korashi LA; Medical Microbiology and Immunology Department, Faculty of Medicine, Zagazig University, Egypt.
  • Khedr EM; Neurology and Psychiatry Department, Assiut University, Assiut, Egypt.
  • Gad D; Chest Department, Faculty of Medicine, Zagazig University, Egypt.
  • Mohamed-Hussein A; Chest Department, Faculty of Medicine, Assiut University, Egypt.
  • Zayed NE; Chest Department, Faculty of Medicine, Zagazig University, Egypt.
  • Mostafa EF; Tropical Medicine and Gastroenterology Department, Alrajhi University Hospital, Assiut University, Assiut, Egypt.
  • Bahgat SM; Family Medicine, Zagazig University, Egypt.
  • Hassany SM; Tropical Medicine and Gastroenterology Department, Alrajhi University Hospital, Assiut University, Assiut, Egypt.
  • Amer MG; Clinical Pathology, Zagazig University, Egypt.
  • El-Mokhtar MA; Medical Microbiology and Immunology Department, Faculty of Medicine, Assiut University, Egypt.
  • Elantouny NG; Internal Medicine, Head Infectious Diseases Unit, Zagazig University, Egypt.
  • Hassan SA; Anesthesia and Intensive Care, Assiut University, Assiut, Egypt.
  • Zarzour AA; Anesthesia and Intensive Care, Assiut University, Assiut, Egypt.
  • Hashem MK; Chest Department, Faculty of Medicine, Assiut University, Egypt.
  • Amin MT; Public Health, Assiut University, Assiut, Egypt.
  • Hassan HM; Medical Microbiology and Immunology Department, Faculty of Medicine, Assiut University, Egypt.
J Infect Public Health ; 14(10): 1474-1480, 2021 Oct.
Article in English | MEDLINE | ID: covidwho-1415574
ABSTRACT

BACKGROUND:

Healthcare workers (HCWs) are at a high risk for disease exposure. Given the limited availability of nucleic acid testing by PCR in low resource settings, serological assays can provide useful data on the proportion of HCWs who have recently or previously been infected. Therefore, in this study, we conducted an immunologic study to determine the seroprevalence of anti-SARS-CoV-2 antibodies in two university hospitals in Egypt.

METHODS:

in this cross sectional study, HCWs who were working in SARS-CoV-2 Isolation Hospitals were interviewed. Estimating specific antibodies (IgM and IgG) against SARS-CoV-2 was carried out using an enzyme-linked immunosorbent assay targeting the Spike antigen of SARS-CoV-2 virus.

RESULTS:

Out of 111, 82 (74%) HCWs accepted to participate with a mean age of 31.5 ± 8.5 years. Anti-SARS-COV2 antibodies were detected in 38/82 (46.3%) of cases with a mean age of 31 years and female HCWs constituted 57.6% of cases. The highest rate of seropositivity was from the nurses (60.5%), and physicians (31.6%) with only (7.9%) technicians. Only 28/82 (34.1%) HCWs reported previous history of COVID19. We reported a statistically significant difference in the timing of exposure (p = 0.010) and the frequency of contact with COVID-19 cases (p = 0.040) between previously infected and on-infected HCWs. Longer time of recovery was reported from IgG positive HCWs (p = 0.036).

CONCLUSION:

The high frequency of seropositive HCWs in investigated hospitals is alarming, especially among asymptomatic personnel. Confirmation of diseased HCWs (among seropositive ones) are warranted.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Female / Humans / Young adult Country/Region as subject: Africa Language: English Journal: J Infect Public Health Journal subject: Communicable Diseases / Public Health Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Female / Humans / Young adult Country/Region as subject: Africa Language: English Journal: J Infect Public Health Journal subject: Communicable Diseases / Public Health Year: 2021 Document Type: Article