SARS-CoV-2 infection in early first-trimester miscarriages: a prospective observational study.
Reprod Biomed Online
; 44(1): 127-130, 2022 01.
Article
in English
| MEDLINE | ID: covidwho-1415750
ABSTRACT
RESEARCH QUESTION Is there an association between SARS-CoV-2 infection and first-trimester miscarriage? DESIGN:
This multicentre prospective study included a cohort of women with first-trimester miscarriages registered consecutively by seven Spanish hospitals where universal PCR screening for SARS-CoV-2 infection was implemented with both miscarriages and deliveries. The incidence of SARS-CoV-2 infection among women with first-trimester miscarriages was compared with the rate registered in women on admission to the delivery ward within the same time frame using a mixed-effects Poisson regression analysis, considering 'hospital' as random effect. The characteristics of SARS-CoV-2 positive and negative patients who miscarried were compared through two-sided univariable analyses.RESULTS:
A total of 301 miscarriages were registered, 11 (3.7%) to SARS-CoV-2 infected and 290 to non-infected women. In the same time frame as the miscarriages, 1936 deliveries were registered, 44 [2.3%] of them were SARS-CoV-2 infected. No differences in terms of SARS-CoV-2 infection incidence were observed between infected miscarriages and infected deliveries (P = 0.233). Regarding the differences observed between miscarriages in SARS-CoV-2 positive and negative women, more inevitable miscarriages occurred in the group of infected women (36.4% versus 16.5% in non-infected women; P = 0.004), and there was greater surgical management of miscarriages (27.3% versus 8.2% in non-infected women; P = 0.036), probably in line with the greater number of inevitable miscarriages observed in this group.CONCLUSIONS:
No association between SARS-CoV-2 infection and risk of first-trimester miscarriage was observed; however, the type of miscarriage seems to differ between SARS-CoV-2 positive and negative women, with inevitable miscarriage being more frequent among infected women.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Abortion, Spontaneous
/
COVID-19
Type of study:
Cohort study
/
Observational study
/
Prognostic study
/
Randomized controlled trials
Topics:
Long Covid
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Middle aged
/
Pregnancy
/
Young adult
Country/Region as subject:
Europa
Language:
English
Journal:
Reprod Biomed Online
Journal subject:
Reproductive Medicine
Year:
2022
Document Type:
Article
Affiliation country:
J.rbmo.2021.09.010
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