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Mucormycosis (black fungus) ensuing COVID-19 and comorbidity meets - Magnifying global pandemic grieve and catastrophe begins.
Pushparaj, Karthika; Kuchi Bhotla, Haripriya; Arumugam, Vijaya Anand; Pappusamy, Manikantan; Easwaran, Murugesh; Liu, Wen-Chao; Issara, Utthapon; Rengasamy, Kannan R R; Meyyazhagan, Arun; Balasubramanian, Balamuralikrishnan.
  • Pushparaj K; Department of Zoology, School of Biosciences, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore 641 043, Tamil Nadu, India.
  • Kuchi Bhotla H; Department of Life Science, CHRIST (Deemed to be University), Bengaluru, Karnataka 560076, India.
  • Arumugam VA; Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641 046, Tamil Nadu, India.
  • Pappusamy M; Department of Life Science, CHRIST (Deemed to be University), Bengaluru, Karnataka 560076, India.
  • Easwaran M; International Centre for Genetic Engineering and Biotechnology, New Delhi 110067, India.
  • Liu WC; Department of Animal Science, College of Coastal Agricultural Sciences, Guangdong Ocean University, Zhanjiang 524088, PR China.
  • Issara U; Division of Food Science and Technology Management, Faculty of Science and Technology, Rajamangala University of Technology Thanyaburi, Pathum Thani 12110, Thailand.
  • Rengasamy KRR; Green Biotechnologies Research Centre of Excellence, University of Limpopo, Private Bag X1106, Polokwane, Sovenga 0727, South Africa.
  • Meyyazhagan A; Department of Life Science, CHRIST (Deemed to be University), Bengaluru, Karnataka 560076, India. Electronic address: arun47biotech@gmail.com.
  • Balasubramanian B; Department of Food Science and Biotechnology, College of Life Science, Sejong University, Seoul 05006, South Korea. Electronic address: bala.m.k@sejong.ac.kr.
Sci Total Environ ; 805: 150355, 2022 Jan 20.
Article in English | MEDLINE | ID: covidwho-1415772
ABSTRACT
Post COVID-19, mucormycosis occurred after the SARS-CoV-2 has rampaged the human population and is a scorching problem among the pandemic globally, particularly among Asian countries. Invasive mucormycosis has been extensively reported from mild to severe COVID-19 survivors. The robust predisposing factor seems to be uncontrolled diabetes mellitus, comorbidity and immunosuppression acquired through steroid therapy. The prime susceptive reason for the increase of mucormycosis cases is elevated iron levels in the serum of the COVID survivors. A panoramic understanding of the infection has been elucidated based on clinical manifestation, genetic and non- genetic mechanisms of steroid drug administration, biochemical pathways and immune modulated receptor associations. This review lime-lights and addresses the "What", "Why", "How" and "When" about the COVID-19 associated mucormycosis (CAM) in a comprehensive manner with a pure intention to bring about awareness to the common public as the cases are inevitably and exponentially increasing in India and global countries as well. The article also unearthed the pathogenesis of mucormycosis and its association with the COVID-19 sequela, the plausible routes of entry, diagnosis and counter remedies to keep the infection at bay. Cohorts of case reports were analysed to spotlight the link between the pandemic COVID-19 and the nightmare-mucormycosis.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Mucormycosis Type of study: Cohort study / Etiology study / Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Sci Total Environ Year: 2022 Document Type: Article Affiliation country: J.scitotenv.2021.150355

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Mucormycosis Type of study: Cohort study / Etiology study / Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Sci Total Environ Year: 2022 Document Type: Article Affiliation country: J.scitotenv.2021.150355