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Natural product-derived phytochemicals as potential agents against coronaviruses: A review.
Mani, Janice S; Johnson, Joel B; Steel, Jason C; Broszczak, Daniel A; Neilsen, Paul M; Walsh, Kerry B; Naiker, Mani.
  • Mani JS; School of Health, Medical and Applied Sciences, CQUniversity, Bruce Hwy, North Rockhampton, QLD, Australia.
  • Johnson JB; School of Health, Medical and Applied Sciences, CQUniversity, Bruce Hwy, North Rockhampton, QLD, Australia.
  • Steel JC; School of Health, Medical and Applied Sciences, CQUniversity, Bruce Hwy, North Rockhampton, QLD, Australia.
  • Broszczak DA; Institute of Health & Biomedical Innovation (Q-Block), Queensland University of Technology, Kelvin Grove Campus, QLD, Australia.
  • Neilsen PM; School of Health, Medical and Applied Sciences, CQUniversity, Bruce Hwy, North Rockhampton, QLD, Australia.
  • Walsh KB; School of Health, Medical and Applied Sciences, CQUniversity, Bruce Hwy, North Rockhampton, QLD, Australia.
  • Naiker M; School of Health, Medical and Applied Sciences, CQUniversity, Bruce Hwy, North Rockhampton, QLD, Australia; Centre for Indigenous Health Equity Research, CQUniversity, Bruce Hwy, North Rockhampton, QLD, Australia. Electronic address: m.naiker@cqu.edu.au.
Virus Res ; 284: 197989, 2020 07 15.
Article in English | MEDLINE | ID: covidwho-141651
ABSTRACT
Coronaviruses are responsible for a growing economic, social and mortality burden, as the causative agent of diseases such as severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), avian infectious bronchitis virus (IBV) and COVID-19. However, there is a lack of effective antiviral agents for many coronavirus strains. Naturally existing compounds provide a wealth of chemical diversity, including antiviral activity, and thus may have utility as therapeutic agents against coronaviral infections. The PubMed database was searched for papers including the keywords coronavirus, SARS or MERS, as well as traditional medicine, herbal, remedy or plants, with 55 primary research articles identified. The overwhelming majority of publications focussed on polar compounds. Compounds that show promise for the inhibition of coronavirus in humans include scutellarein, silvestrol, tryptanthrin, saikosaponin B2, quercetin, myricetin, caffeic acid, psoralidin, isobavachalcone, and lectins such as griffithsin. Other compounds such as lycorine may be suitable if a therapeutic level of antiviral activity can be achieved without exceeding toxic plasma concentrations. It was noted that the most promising small molecules identified as coronavirus inhibitors contained a conjugated fused ring structure with the majority being classified as being polyphenols.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Phytochemicals / Betacoronavirus Type of study: Reviews Topics: Traditional medicine Limits: Animals / Humans Language: English Journal: Virus Res Journal subject: Virology Year: 2020 Document Type: Article Affiliation country: J.virusres.2020.197989

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Phytochemicals / Betacoronavirus Type of study: Reviews Topics: Traditional medicine Limits: Animals / Humans Language: English Journal: Virus Res Journal subject: Virology Year: 2020 Document Type: Article Affiliation country: J.virusres.2020.197989