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The United Kingdom Research study into Ethnicity And COVID-19 outcomes in Healthcare workers (UK-REACH): protocol for a prospective longitudinal cohort study of healthcare and ancillary workers in UK healthcare settings.
Woolf, Katherine; Melbourne, Carl; Bryant, Luke; Guyatt, Anna L; McManus, I Chris; Gupta, Amit; Free, Robert C; Nellums, Laura; Carr, Sue; John, Catherine; Martin, Christopher A; Wain, Louise V; Gray, Laura J; Garwood, Claire; Modhwadia, Vishant; Abrams, Keith R; Tobin, Martin D; Khunti, Kamlesh; Pareek, Manish.
  • Woolf K; Research Department of Medical Education, University College London, London, UK.
  • Melbourne C; Genetic Epidemiology Research Group, Department of Health Sciences, University of Leicester, Leicester, UK.
  • Bryant L; Department of Respiratory Sciences, University of Leicester, Leicester, UK.
  • Guyatt AL; Genetic Epidemiology Research Group, Department of Health Sciences, University of Leicester, Leicester, UK.
  • McManus IC; Research Department of Medical Education, University College London, London, UK.
  • Gupta A; Oxford University Hospitals NHS Foundation Trust, Oxford, Oxfordshire, UK.
  • Free RC; Department of Respiratory Sciences, University of Leicester, Leicester, UK.
  • Nellums L; NIHR Leicester Biomedical Research Centre Respiratory Diseases, Leicester, East Midlands, UK.
  • Carr S; Division of Epidemiology and Public Health, University of Nottingham, Nottingham, UK.
  • John C; University Hospitals of Leicester NHS Trust, Leicester, UK.
  • Martin CA; General Medical Council, London, UK.
  • Wain LV; Department of Health Sciences, University of Leicester, Leicester, UK.
  • Gray LJ; Department of Respiratory Sciences, University of Leicester, Leicester, UK.
  • Garwood C; Department of Infection and HIV Medicine, University Hospitals of Leicester NHS Trust, Leicester, UK.
  • Modhwadia V; NIHR Leicester Biomedical Research Centre Respiratory Diseases, Leicester, East Midlands, UK.
  • Abrams KR; Department of Health Sciences, University of Leicester, Leicester, UK.
  • Tobin MD; Department of Health Sciences, University of Leicester, Leicester, UK.
  • Khunti K; Department of Respiratory Sciences, University of Leicester, Leicester, UK.
  • Pareek M; Department of Respiratory Sciences, University of Leicester, Leicester, UK.
BMJ Open ; 11(9): e050647, 2021 09 17.
Article in English | MEDLINE | ID: covidwho-1416675
Preprint
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ABSTRACT

INTRODUCTION:

The COVID-19 pandemic has resulted in significant morbidity and mortality and devastated economies globally. Among groups at increased risk are healthcare workers (HCWs) and ethnic minority groups. Emerging evidence suggests that HCWs from ethnic minority groups are at increased risk of adverse COVID-19-related outcomes. To date, there has been no large-scale analysis of these risks in UK HCWs or ancillary workers in healthcare settings, stratified by ethnicity or occupation, and adjusted for confounders. This paper reports the protocol for a prospective longitudinal questionnaire study of UK HCWs, as part of the UK-REACH programme (The United Kingdom Research study into Ethnicity And COVID-19 outcomes in Healthcare workers). METHODS AND

ANALYSIS:

A baseline questionnaire will be administered to a national cohort of UK HCWs and ancillary workers in healthcare settings, and those registered with UK healthcare regulators, with follow-up questionnaires administered at 4 and 8 months. With consent, questionnaire data will be linked to health records with 25-year follow-up. Univariate associations between ethnicity and clinical COVID-19 outcomes, physical and mental health, and key confounders/explanatory variables will be tested. Multivariable analyses will test for associations between ethnicity and key outcomes adjusted for the confounder/explanatory variables. We will model changes over time by ethnic group, facilitating understanding of absolute and relative risks in different ethnic groups, and generalisability of findings. ETHICS AND DISSEMINATION The study is approved by Health Research Authority (reference 20/HRA/4718), and carries minimal risk. We aim to manage the small risk of participant distress about questions on sensitive topics by clearly participant information that the questionnaire covers sensitive topics and there is no obligation to answer these or any other questions, and by providing support organisation links. Results will be disseminated with reports to Government and papers submitted to pre-print servers and peer reviewed journals. TRIAL REGISTRATION NUMBER ISRCTN11811602; Pre-results.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Ethnicity / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Humans Country/Region as subject: Europa Language: English Journal: BMJ Open Year: 2021 Document Type: Article Affiliation country: Bmjopen-2021-050647

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Ethnicity / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Humans Country/Region as subject: Europa Language: English Journal: BMJ Open Year: 2021 Document Type: Article Affiliation country: Bmjopen-2021-050647