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Imaging Findings for Identifying and Evaluating Complications After Lung Transplantation in Patients with Advanced COVID-19: Two Case Reports.
Pan, Junhan; Zhu, Manhua; Han, Weili; Chen, Feng.
  • Pan J; Department of Radiology, Zhejiang University School of Medicine First Affiliated Hospital, No.79 Qingchun Road, Hangzhou, 310003, China.
  • Zhu M; Department of Lung Transplantation, Zhejiang University School of Medicine First Affiliated Hospital, No.79 Qingchun Road, Hangzhou, 310003, China.
  • Han W; Department of Lung Transplantation, Zhejiang University School of Medicine First Affiliated Hospital, No.79 Qingchun Road, Hangzhou, 310003, China.
  • Chen F; Department of Radiology, Zhejiang University School of Medicine First Affiliated Hospital, No.79 Qingchun Road, Hangzhou, 310003, China.
Curr Med Imaging ; 18(4): 440-443, 2022.
Article in English | MEDLINE | ID: covidwho-1417027
ABSTRACT

BACKGROUND:

Lung transplantation might be a viable alternative for patients with irreversible lung injury secondary to coronavirus disease 2019 (COVID-19). Here, we describe two patients with end-stage COVID-19 that received lung transplantations, the clinical-radiologic manifestations of postoperative complications, and the imaging features of allograft rejection. CASE PRESENTATION In case 1, a 66-year-old woman presented severe hypoxia after lung transplantation. Chest imaging revealed diffuse homogeneous infiltration in the donor's lung. Dramatic resolution of the imaging abnormalities after intravenous administration of methylprednisolone favored a diagnosis of hyperacute rejection. The second is a 70-year-old man who was infected with bacterial postoperatively. During the empiric antibiotic therapy, chest CT showed newly developed groundglass opacities with septal thickening, suggesting a diagnosis of acute rejection. High-dose corticosteroids therapy was initiated, and the patient recovered gradually.

CONCLUSION:

This is the first report describing postoperative complications of lung transplantation in patients with advanced COVID-19. We presumed that imaging procedures could be a useful tool in early detecting lung transplant complications and selecting specific interventions for patients with COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Lung Transplantation / COVID-19 Type of study: Case report / Experimental Studies / Prognostic study Limits: Aged / Female / Humans / Male Language: English Journal: Curr Med Imaging Year: 2022 Document Type: Article Affiliation country: 1573405617666210917125045

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Lung Transplantation / COVID-19 Type of study: Case report / Experimental Studies / Prognostic study Limits: Aged / Female / Humans / Male Language: English Journal: Curr Med Imaging Year: 2022 Document Type: Article Affiliation country: 1573405617666210917125045