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Sex Differences in Immunity to Viral Infections.
Jacobsen, Henning; Klein, Sabra L.
  • Jacobsen H; W. Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.
  • Klein SL; W. Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.
Front Immunol ; 12: 720952, 2021.
Article in English | MEDLINE | ID: covidwho-1417084
ABSTRACT
The ongoing COVID-19 pandemic has increased awareness about sex-specific differences in immunity and outcomes following SARS-CoV-2 infection. Strong evidence of a male bias in COVID-19 disease severity is hypothesized to be mediated by sex differential immune responses against SARS-CoV-2. This hypothesis is based on data from other viral infections, including influenza viruses, HIV, hepatitis viruses, and others that have demonstrated sex-specific immunity to viral infections. Although males are more susceptible to most viral infections, females possess immunological features that render them more vulnerable to distinct immune-related disease outcomes. Both sex chromosome complement and related genes as well as sex steroids play important roles in mediating the development of sex differences in immunity to viral infections.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Severity of Illness Index / Sex Characteristics / COVID-19 Type of study: Prognostic study Limits: Female / Humans / Male Language: English Journal: Front Immunol Year: 2021 Document Type: Article Affiliation country: Fimmu.2021.720952

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Severity of Illness Index / Sex Characteristics / COVID-19 Type of study: Prognostic study Limits: Female / Humans / Male Language: English Journal: Front Immunol Year: 2021 Document Type: Article Affiliation country: Fimmu.2021.720952