Your browser doesn't support javascript.
Development of epitope-based peptide vaccine against novel coronavirus 2019 (SARS-COV-2): Immunoinformatics approach.
Bhattacharya, Manojit; Sharma, Ashish R; Patra, Prasanta; Ghosh, Pratik; Sharma, Garima; Patra, Bidhan C; Lee, Sang-Soo; Chakraborty, Chiranjib.
  • Bhattacharya M; Institute for Skeletal Aging and Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon-si, Gangwon-do, Republic of Korea.
  • Sharma AR; Department of Zoology, Vidyasagar University, Midnapore, West Bengal, India.
  • Patra P; Institute for Skeletal Aging and Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon-si, Gangwon-do, Republic of Korea.
  • Ghosh P; Department of Zoology, Vidyasagar University, Midnapore, West Bengal, India.
  • Sharma G; Department of Zoology, Vidyasagar University, Midnapore, West Bengal, India.
  • Patra BC; Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chuncheon, Republic of Korea.
  • Lee SS; Department of Zoology, Vidyasagar University, Midnapore, West Bengal, India.
  • Chakraborty C; Institute for Skeletal Aging and Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon-si, Gangwon-do, Republic of Korea.
J Med Virol ; 92(6): 618-631, 2020 06.
Article in English | MEDLINE | ID: covidwho-141989
ABSTRACT
Recently, a novel coronavirus (SARS-COV-2) emerged which is responsible for the recent outbreak in Wuhan, China. Genetically, it is closely related to SARS-CoV and MERS-CoV. The situation is getting worse and worse, therefore, there is an urgent need for designing a suitable peptide vaccine component against the SARS-COV-2. Here, we characterized spike glycoprotein to obtain immunogenic epitopes. Next, we chose 13 Major Histocompatibility Complex-(MHC) I and 3 MHC-II epitopes, having antigenic properties. These epitopes are usually linked to specific linkers to build vaccine components and molecularly dock on toll-like receptor-5 to get binding affinity. Therefore, to provide a fast immunogenic profile of these epitopes, we performed immunoinformatics analysis so that the rapid development of the vaccine might bring this disastrous situation to the end earlier.
Subject(s)
Betacoronavirus/immunology; Coronavirus Infections/prevention & control; Epitopes, B-Lymphocyte/chemistry; Epitopes, T-Lymphocyte/chemistry; Pandemics/prevention & control; Pneumonia, Viral/prevention & control; Spike Glycoprotein, Coronavirus/chemistry; Toll-Like Receptor 5/chemistry; Viral Vaccines/chemistry; Amino Acid Sequence; Betacoronavirus/genetics; Betacoronavirus/pathogenicity; Binding Sites; COVID-19; COVID-19 Vaccines; Computational Biology/methods; Coronavirus Infections/immunology; Coronavirus Infections/virology; Epitopes/chemistry; Epitopes/genetics; Epitopes/immunology; Epitopes, B-Lymphocyte/genetics; Epitopes, B-Lymphocyte/immunology; Epitopes, T-Lymphocyte/genetics; Epitopes, T-Lymphocyte/immunology; Histocompatibility Antigens Class I/chemistry; Histocompatibility Antigens Class I/genetics; Histocompatibility Antigens Class I/immunology; Histocompatibility Antigens Class II/chemistry; Histocompatibility Antigens Class II/genetics; Histocompatibility Antigens Class II/immunology; Humans; Middle East Respiratory Syndrome Coronavirus/genetics; Middle East Respiratory Syndrome Coronavirus/immunology; Middle East Respiratory Syndrome Coronavirus/pathogenicity; Molecular Docking Simulation; Pneumonia, Viral/immunology; Pneumonia, Viral/virology; Protein Binding; Protein Interaction Domains and Motifs; Protein Structure, Tertiary; Severe acute respiratory syndrome-related coronavirus/genetics; Severe acute respiratory syndrome-related coronavirus/immunology; Severe acute respiratory syndrome-related coronavirus/pathogenicity; SARS-CoV-2; Spike Glycoprotein, Coronavirus/genetics; Spike Glycoprotein, Coronavirus/immunology; Toll-Like Receptor 5/genetics; Toll-Like Receptor 5/immunology; Vaccines, Subunit; Viral Vaccines/immunology
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Viral Vaccines / Coronavirus Infections / Epitopes, T-Lymphocyte / Epitopes, B-Lymphocyte / Toll-Like Receptor 5 / Pandemics / Spike Glycoprotein, Coronavirus / Betacoronavirus Topics: Vaccines Language: English Journal: J Med Virol Year: 2020 Document Type: Article

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Viral Vaccines / Coronavirus Infections / Epitopes, T-Lymphocyte / Epitopes, B-Lymphocyte / Toll-Like Receptor 5 / Pandemics / Spike Glycoprotein, Coronavirus / Betacoronavirus Topics: Vaccines Language: English Journal: J Med Virol Year: 2020 Document Type: Article