Repurposing an Antiviral Drug against SARS-CoV-2 Main Protease.

Sarkar, Arighna; Mandal, Kalyaneswar

Sarkar, Arighna; Mandal, Kalyaneswar.

Sarkar A; TIFR Centre for Interdisciplinary Sciences, Tata Institute of Fundamental Research Hyderabad, 36/p Gopanpally, Hyderabad, Telangana, 500046, India.
Mandal K; TIFR Centre for Interdisciplinary Sciences, Tata Institute of Fundamental Research Hyderabad, 36/p Gopanpally, Hyderabad, Telangana, 500046, India.

Angew Chem Int Ed Engl ; 60(44): 23492-23494, 2021 10 25.

Article in English | MEDLINE | ID: covidwho-1427056

ABSTRACT

ABSTRACT

This article highlights recent pioneering work by Günther etâal. towards the discovery of potential repurposed antiviral compounds (peptidomimetic and non-peptidic) against the SARS-CoV-2 main protease (Mpro ). The antiviral activity of the most potent drugs is discussed along with their binding mode to Mpro as observed through X-ray crystallographic screening.

Subject(s)

Antiviral Agents/pharmacology; Coronavirus 3C Proteases/antagonists & inhibitors; Drug Repositioning; Protease Inhibitors/pharmacology; SARS-CoV-2/enzymology; Allosteric Site; Animals; Antiviral Agents/chemistry; Chlorocebus aethiops; Crystallography, X-Ray; Molecular Structure; Protease Inhibitors/chemistry; Vero Cells

Keywords

SARS-CoV-2; X-ray crystallographic screening; allosteric inhibitors; antiviral drugs; drug screening

Fulltext

XML

PubMed Links

Search on Google

Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Protease Inhibitors / Drug Repositioning / Coronavirus 3C Proteases / SARS-CoV-2 Limits: Animals Language: English Journal: Angew Chem Int Ed Engl Year: 2021 Document Type: Article Affiliation country: Anie.202107481

Similar

MEDLINE

LILACS

LIS

Fulltext

XML

PubMed Links

Search on Google