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Arginine vasopressin and pathophysiology of COVID-19: An innovative perspective.
Al-Kuraishy, Hayder M; Al-Gareeb, Ali I; Qusti, Safaa; Alshammari, Eida M; Atanu, Francis O; Batiha, Gaber El-Saber.
  • Al-Kuraishy HM; Department of Clinical Pharmacology and Medicine, College of Medicine, ALmustansiriyia University, Baghdad, Iraq. Electronic address: Hayderm36@yahoo.com.
  • Al-Gareeb AI; Department of Clinical Pharmacology and Medicine, College of Medicine, ALmustansiriyia University, Baghdad, Iraq. Electronic address: Dr.alialgareeb78@yahoo.com.
  • Qusti S; Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia. Electronic address: squsti@kau.edu.sa.
  • Alshammari EM; Department of Chemistry, College of Sciences, University of Ha'il, Ha'il, Saudi Arabia. Electronic address: eida.alshammari@uoh.edu.sa.
  • Atanu FO; Department of Biochemistry, Faculty of Natural Sciences, Kogi State University, P.M.B. 1008 Anyigba, Nigeria. Electronic address: atanufo@gmail.com.
  • Batiha GE; Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour 22511, AlBeheira, Egypt. Electronic address: dr_gaber_batiha@vetmed.dmu.edu.eg.
Biomed Pharmacother ; 143: 112193, 2021 Nov.
Article in English | MEDLINE | ID: covidwho-1427620
ABSTRACT
In Covid-19, systemic disturbances may progress due to development of cytokine storm and dysregulation of and plasma osmolarility due to high release of pro-inflammatory cytokines and neuro-hormonal disorders. Arginine vasopressin (AVP) which is involve in the regulation of body osmotic system, body water content, blood pressure and plasma volume, that are highly disturbed in Covid-19 and linked with poor clinical outcomes. Therefore, this present study aimed to find the potential association between AVP serum level and inflammatory disorders in Covid-19. It has been observed by different recent studies that physiological response due to fever, pain, hypovolemia, dehydration, and psychological stress is characterized by activation release of AVP to counter-balance high blood viscosity in Covid-19 patients. In addition, activated immune cells mainly T and B lymphocytes and released pro-inflammatory cytokines stimulate discharge of stored AVP from immune cells, which in a vicious cycle trigger release of pro-inflammatory cytokines. Vasopressin receptor antagonists have antiviral and anti-inflammatory effects that may inhibit AVP-induced hyponatremia and release of pro-inflammatory cytokines in Covid-19. In conclusion, release of AVP from hypothalamus is augmented in Covid-19 due to stress, high pro-inflammatory cytokines, high circulating AngII and inhibition of GABAergic neurons. In turn, high AVP level leads to induction of hyponatremia, inflammatory disorders, and development of complications in Covid-19 by activation of NF-κB and NLRP3 inflammasome with release of pro-inflammatory cytokines. Therefore, AVP antagonists might be novel potential therapeutic modality in treating Covid-19 through mitigation of AVP-mediated inflammatory disorders and hyponatremia.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Arginine Vasopressin / COVID-19 / COVID-19 Drug Treatment Type of study: Prognostic study Limits: Humans Language: English Journal: Biomed Pharmacother Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Arginine Vasopressin / COVID-19 / COVID-19 Drug Treatment Type of study: Prognostic study Limits: Humans Language: English Journal: Biomed Pharmacother Year: 2021 Document Type: Article