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Surveillance of adverse drug events associated with tocilizumab in hospitalized veterans with coronavirus disease 2019 (COVID-19) to inform patient safety and pandemic preparedness.
Datta, Rupak; Barrett, Alexis; Burk, Muriel; Salone, Cedric; Au, Anthony; Cunningham, Francesca; Fisher, Ann; Dembry, Louise Marie; Akgün, Kathleen M.
  • Datta R; Hospital Epidemiology and Infection Prevention Program, Veterans Affairs (VA) Connecticut Healthcare System, West Haven, Connecticut.
  • Barrett A; Section of Infectious Diseases, Yale School of Medicine, New Haven, Connecticut.
  • Burk M; VA Pharmacy Benefits Management Services and Center for Medication Safety, Hines VA, Hines, Illinois.
  • Salone C; VA Pharmacy Benefits Management Services and Center for Medication Safety, Hines VA, Hines, Illinois.
  • Au A; VA Pharmacy Benefits Management Services and Center for Medication Safety, Hines VA, Hines, Illinois.
  • Cunningham F; VA Pharmacy Benefits Management Services and Center for Medication Safety, Hines VA, Hines, Illinois.
  • Fisher A; VA Pharmacy Benefits Management Services and Center for Medication Safety, Hines VA, Hines, Illinois.
  • Dembry LM; Hospital Epidemiology and Infection Prevention Program, Veterans Affairs (VA) Connecticut Healthcare System, West Haven, Connecticut.
  • Akgün KM; Section of Infectious Diseases, Yale School of Medicine, New Haven, Connecticut.
Infect Control Hosp Epidemiol ; 43(10): 1488-1491, 2022 10.
Article in English | MEDLINE | ID: covidwho-1428666
ABSTRACT
We evaluated adverse drug events (ADEs) by chart review in a random national sample of 428 veterans with coronavirus disease 2019 (COVID-19) who received tocilizumab (n = 173 of 428). ADEs (median time, 5 days) occurred in 51 of 173 (29%) and included hepatoxicity (n = 29) and infection (n = 13). Concomitant medication discontinuation occurred in 22% of ADE patients; mortality was 39%.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Veterans / Drug-Related Side Effects and Adverse Reactions / COVID-19 Type of study: Experimental Studies / Randomized controlled trials Limits: Humans Language: English Journal: Infect Control Hosp Epidemiol Journal subject: Communicable Diseases / Nursing / Epidemiology / Hospitals Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Veterans / Drug-Related Side Effects and Adverse Reactions / COVID-19 Type of study: Experimental Studies / Randomized controlled trials Limits: Humans Language: English Journal: Infect Control Hosp Epidemiol Journal subject: Communicable Diseases / Nursing / Epidemiology / Hospitals Year: 2022 Document Type: Article