Structural biology of SARS-CoV-2 and implications for therapeutic development.
Nat Rev Microbiol
; 19(11): 685-700, 2021 11.
Article
in English
| MEDLINE | ID: covidwho-1428872
ABSTRACT
The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an unprecedented global health crisis. However, therapeutic options for treatment are still very limited. The development of drugs that target vital proteins in the viral life cycle is a feasible approach for treating COVID-19. Belonging to the subfamily Orthocoronavirinae with the largest RNA genome, SARS-CoV-2 encodes a total of 29 proteins. These non-structural, structural and accessory proteins participate in entry into host cells, genome replication and transcription, and viral assembly and release. SARS-CoV-2 proteins can individually perform essential physiological roles, be components of the viral replication machinery or interact with numerous host cellular factors. In this Review, we delineate the structural features of SARS-CoV-2 from the whole viral particle to the individual viral proteins and discuss their functions as well as their potential as targets for therapeutic interventions.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Viral Proteins
/
SARS-CoV-2
/
COVID-19 Drug Treatment
Language:
English
Journal:
Nat Rev Microbiol
Journal subject:
Microbiology
Year:
2021
Document Type:
Article
Affiliation country:
S41579-021-00630-8
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