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A case of Guillain-Barre syndrome following Pfizer COVID-19 vaccine.
Rao, Shiavax J; Khurana, Sahiba; Murthy, Gayathri; Dawson, Elliot T; Jazebi, Noushin; Haas, Christopher J.
  • Rao SJ; Department of Medicine, MedStar Union Memorial Hospital, Baltimore, MD, USA.
  • Khurana S; Department of Medicine, MedStar Union Memorial Hospital, Baltimore, MD, USA.
  • Murthy G; Department of Medicine, MedStar Harbor Hospital, Baltimore, MD, USA.
  • Dawson ET; Department of Medicine, MedStar Franklin Square Medical Center, Baltimore, MD, USA.
  • Jazebi N; Department of Neurology, MedStar Franklin Square Medical Center, Baltimore, MD, USA.
  • Haas CJ; Neurology, Georgetown University Medical Center, Washington, DC, USA.
J Community Hosp Intern Med Perspect ; 11(5): 597-600, 2021.
Article in English | MEDLINE | ID: covidwho-1429117
ABSTRACT
Since the first-reported case of Severe Acute Respiratory Distress Syndrome-Coronavirus 2 in December 2019, COVID-19 has caused a global pandemic associated with significant morbidity and mortality. After a year of advances in vaccine research and development, three vaccines for the prevention of COVID-19 (manufactured by Pfizer, Moderna and Johnson & Johnson's Janssen Biotech) are approved for use in the USA. We report the first case of Guillain-Barre Syndrome after receiving the second dose of the Pfizer COVID-19 vaccine, in a 42-year-old woman presenting with progressive ascending weakness and paresthesias. Diagnostic workup demonstrated cytoalbuminologic dissociation on cerebrospinal fluid analysis with confirmatory evidence of early demyelinating electrodiagnostic features on nerve conduction study and an extensive serological workup being negative for other viral or autoimmune disease triggers. Management included administration of intravenous immunoglobulin (total of 2 gm/kg), with frequent monitoring of forced vital capacity and negative inspiratory force. A longitudinal risk profile of neurologic complications caused from COVID-19 vaccines remains limited, and prompt recognition of potential neurological complications from the COVID-19 vaccine is of interest to public health.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Case report / Prognostic study Topics: Vaccines Language: English Journal: J Community Hosp Intern Med Perspect Year: 2021 Document Type: Article Affiliation country: 20009666.2021.1954284

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Case report / Prognostic study Topics: Vaccines Language: English Journal: J Community Hosp Intern Med Perspect Year: 2021 Document Type: Article Affiliation country: 20009666.2021.1954284