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Liver or Kidney Transplantation After SARS-CoV-2 Infection: Prevalence, Short-term Outcome, and Kinetics of Serum IgG Antibodies.
Verbeek, Jef; Vrij, Casper; Vermeersch, Pieter; Van Elslande, Jan; Vets, Sofie; Lagrou, Katrien; Vos, Robin; van Cleemput, Johan; Jochmans, Ina; Monbaliu, Diethard; Pirenne, Jacques; Kuypers, Dirk; Nevens, Frederik.
  • Verbeek J; Department of Gastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium.
  • Vrij C; Laboratory of Hepatology, Department of Chronic Diseases and Metabolism (CHROMETA), KU Leuven, Leuven, Belgium.
  • Vermeersch P; Department of Gastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium.
  • Van Elslande J; Laboratory of Hepatology, Department of Chronic Diseases and Metabolism (CHROMETA), KU Leuven, Leuven, Belgium.
  • Vets S; Clinical Department of Laboratory Medicine and National Reference Center for Respiratory Pathogens, University Hospitals Leuven, Leuven, Belgium.
  • Lagrou K; Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium.
  • Vos R; Clinical Department of Laboratory Medicine and National Reference Center for Respiratory Pathogens, University Hospitals Leuven, Leuven, Belgium.
  • van Cleemput J; Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium.
  • Jochmans I; Department of Abdominal Transplant Surgery, University Hospitals Leuven, Leuven, Belgium.
  • Monbaliu D; Transplantation Research Group, Lab of Abdominal Transplantation, Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium.
  • Pirenne J; Clinical Department of Laboratory Medicine and National Reference Center for Respiratory Pathogens, University Hospitals Leuven, Leuven, Belgium.
  • Kuypers D; Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium.
  • Nevens F; Department of Respiratory Diseases, University Hospitals Leuven, Leuven, Belgium.
Transplantation ; 106(4): 862-868, 2022 04 01.
Article in English | MEDLINE | ID: covidwho-1429378
ABSTRACT

BACKGROUND:

There is a paucity of data on the prevalence, adequate timing, and outcome of solid organ transplantation after severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection and the kinetics of immunoglobulin G (IgG) antibodies in these patients.

METHODS:

SARS-CoV-2 antinucleocapsid (N) IgG and polymerase chain reaction via a nasopharyngeal swab were analyzed in all patients within 24 h before liver or kidney transplantation. Kinetics of IgG antibodies were analyzed and compared with an immunocompetent cohort.

RESULTS:

Between May 1, 2020, and March 18, 2021, 168 patients underwent liver or kidney transplantation in our center, of which 11 (6.54%) patients with a previous SARS-CoV-2 infection were identified. The median interval between SARS-CoV-2 infection and transplantation was 4.5 mo (range, 0.9-11). After a median posttransplant follow-up of 4.9 mo, 10 out of 11 patients were alive without clinical signs of viral shedding or recurrent or active infection. One patient without symptom resolution at time of transplantation died after combined liver-kidney transplantation. In 9 out of 11 patients with previously polymerase chain reaction-confirmed infection, SARS-CoV-2 anti-N and antispike (S) IgG were detectable at day of transplantation. Absolute levels of anti-N and anti-S IgG were positively correlated, declined over time in all patients, and were significantly lower compared with immunocompetent individuals. All patients remained anti-S IgG positive until the last posttransplant follow-up, whereas 3 patients became anti-N negative.

CONCLUSIONS:

We observed an uncomplicated course of liver or kidney transplantation after SARS-CoV-2 infection in selected patients. Although having lower absolute IgG antibody levels than immunocompetent individuals, all seroconverted patients remained anti-S IgG positive. These encouraging data need validation in larger studies.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Kidney Transplantation / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Limits: Humans Language: English Journal: Transplantation Year: 2022 Document Type: Article Affiliation country: TP.0000000000003955

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Kidney Transplantation / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Limits: Humans Language: English Journal: Transplantation Year: 2022 Document Type: Article Affiliation country: TP.0000000000003955