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Human Ace D/I Polymorphism Could Affect the Clinicobiological Course of COVID-19.
Aladag, Elifcan; Tas, Zahit; Ozdemir, Bilgesu Safak; Akbaba, Tayfun Hilmi; Akpinar, Meltem Gulsun; Goker, Hakan; Unalan-Altintop, Tugce; Inkaya, Ahmet Cagkan; Alp, Alpaslan; Metan, Gokhan; Haznedaroglu, Ibrahim Celalettin; Balci-Peynircioglu, Banu; Sayinalp, Nilgun.
  • Aladag E; Department of Hematology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
  • Tas Z; Department of Infectious Diseases, Hacettepe University Faculty of Medicine, Ankara, Turkey.
  • Ozdemir BS; Department of Medical Biology and Genetics, Hacettepe University Faculty of Medicine, Ankara, Turkey.
  • Akbaba TH; Department of Medical Biology and Genetics, Hacettepe University Faculty of Medicine, Ankara, Turkey.
  • Akpinar MG; Department of Radiology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
  • Goker H; Department of Hematology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
  • Unalan-Altintop T; Department of Microbiology and Clinical Microbiology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
  • Inkaya AC; Department of Infectious Diseases, Hacettepe University Faculty of Medicine, Ankara, Turkey.
  • Alp A; Department of Microbiology and Clinical Microbiology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
  • Metan G; Department of Infectious Diseases, Hacettepe University Faculty of Medicine, Ankara, Turkey.
  • Haznedaroglu IC; Department of Hematology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
  • Balci-Peynircioglu B; Department of Medical Biology and Genetics, Hacettepe University Faculty of Medicine, Ankara, Turkey.
  • Sayinalp N; Department of Hematology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
J Renin Angiotensin Aldosterone Syst ; 2021: 5509280, 2021.
Article in English | MEDLINE | ID: covidwho-1430254
ABSTRACT

INTRODUCTION:

The coronavirus disease 2019 (COVID-19), that is caused by severe acute respiratory syndrome corona virus 2 (SARS-CoV-2), has spread rapidly worldwide since December 2019. The SARS-CoV-2 virus has a great affinity for the angiotensin-converting enzyme-2 (ACE-2) receptor, which is an essential element of the renin-angiotensin system (RAS). This study is aimed at assessing the impact of the angiotensin-converting enzyme (ACE) gene insertion (I)/deletion (D) polymorphisms, on the susceptibility and clinical outcomes of the COVID-19 immunoinflammatory syndrome. Patients and Methods. A total of 112 patients diagnosed with COVID-19 between 1 and 15 May 2020 were enrolled in the study. ACE gene allele frequencies were compared to the previously reported Turkish population comprised of 300 people.

RESULTS:

The most common genotype in the patients and control group was DI with 53% and II with 42%, respectively. The difference in the presence of the D allele between the patient and control groups was statistically significant (67% vs. 42%, respectively, p < 0.0001). Severe pneumonia was observed more in patients with DI allele (31%) than DD (8%) and II (0%) (p = 0.021). The mortality rate, time to defervescence, and the hospitalization duration were not different between the genotype groups.

CONCLUSION:

Genotype DI of ACE I/D polymorphism is associated with the infectious rate particularly severe pneumonia in this study conducted in the Turkish population. Therefore, ACE D/I polymorphism could affect the clinical course of COVID-19.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Peptidyl-Dipeptidase A / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: J Renin Angiotensin Aldosterone Syst Journal subject: Physiology Year: 2021 Document Type: Article Affiliation country: 2021

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Peptidyl-Dipeptidase A / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: J Renin Angiotensin Aldosterone Syst Journal subject: Physiology Year: 2021 Document Type: Article Affiliation country: 2021