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Tuberculosis related disability: a systematic review and meta-analysis.
Alene, Kefyalew Addis; Wangdi, Kinley; Colquhoun, Samantha; Chani, Kudakwashe; Islam, Tauhid; Rahevar, Kalpeshsinh; Morishita, Fukushi; Byrne, Anthony; Clark, Justin; Viney, Kerri.
  • Alene KA; Faculty of Health Sciences, Curtin University, Kent St, Bentley, Perth, 6102, Western Australia, Australia.
  • Wangdi K; Telethon Kids Institute, 15 Hospital Ave, Nedlands, Perth, Western Australia, 6009, Australia.
  • Colquhoun S; Research School of Population Health, The Australian National University, 62 Mills Road, Acton, Canberra, ACT, 2601, Australia.
  • Chani K; Research School of Population Health, The Australian National University, 62 Mills Road, Acton, Canberra, ACT, 2601, Australia.
  • Islam T; Research School of Population Health, The Australian National University, 62 Mills Road, Acton, Canberra, ACT, 2601, Australia. samantha.colquhoun@anu.edu.au.
  • Rahevar K; Research School of Population Health, The Australian National University, 62 Mills Road, Acton, Canberra, ACT, 2601, Australia.
  • Morishita F; World Health Organization (WHO) Regional Office for the Western Pacific, The Philippines, Manila, Philippines.
  • Byrne A; World Health Organization (WHO) Regional Office for the Western Pacific, The Philippines, Manila, Philippines.
  • Clark J; World Health Organization (WHO) Regional Office for the Western Pacific, The Philippines, Manila, Philippines.
  • Viney K; St Vincent's Hospital, Sydney, 406 Victoria St, Darlinghurst, Sydney, 2010, New South Wales, Australia.
BMC Med ; 19(1): 203, 2021 09 09.
Article in English | MEDLINE | ID: covidwho-1430426
ABSTRACT

BACKGROUND:

The sustainable development goals aim to improve health for all by 2030. They incorporate ambitious goals regarding tuberculosis (TB), which may be a significant cause of disability, yet to be quantified. Therefore, we aimed to quantify the prevalence and types of TB-related disabilities.

METHODS:

We performed a systematic review of TB-related disabilities. The pooled prevalence of disabilities was calculated using the inverse variance heterogeneity model. The maps of the proportions of common types of disabilities by country income level were created.

RESULTS:

We included a total of 131 studies (217,475 patients) that were conducted in 49 countries. The most common type of disabilities were mental health disorders (23.1%), respiratory impairment (20.7%), musculoskeletal impairment (17.1%), hearing impairment (14.5%), visual impairment (9.8%), renal impairment (5.7%), and neurological impairment (1.6%). The prevalence of respiratory impairment (61.2%) and mental health disorders (42.0%) was highest in low-income countries while neurological impairment was highest in lower middle-income countries (25.6%). Drug-resistant TB was associated with respiratory (58.7%), neurological (37.2%), and hearing impairments (25.0%) and mental health disorders (26.0%), respectively.

CONCLUSIONS:

TB-related disabilities were frequently reported. More uniform reporting tools for TB-related disability and further research to better quantify and mitigate it are urgently needed. PROSPERO REGISTRATION NUMBER CRD42019147488.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Tuberculosis / Disabled Persons / Tuberculosis, Multidrug-Resistant / Mental Disorders Type of study: Observational study / Reviews / Systematic review/Meta Analysis Limits: Humans Language: English Journal: BMC Med Journal subject: Medicine Year: 2021 Document Type: Article Affiliation country: S12916-021-02063-9

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Tuberculosis / Disabled Persons / Tuberculosis, Multidrug-Resistant / Mental Disorders Type of study: Observational study / Reviews / Systematic review/Meta Analysis Limits: Humans Language: English Journal: BMC Med Journal subject: Medicine Year: 2021 Document Type: Article Affiliation country: S12916-021-02063-9