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Sample Preparation and Diagnostic Methods for a Variety of Settings: A Comprehensive Review.
Nichols, Zach E; Geddes, Chris D.
  • Nichols ZE; Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, 1000 Hilltop Drive, Baltimore, MD 21250, USA.
  • Geddes CD; Institute of Fluorescence, University of Maryland, Baltimore County, 701 E Pratt Street, Baltimore, MD 21270, USA.
Molecules ; 26(18)2021 Sep 18.
Article in English | MEDLINE | ID: covidwho-1430926
ABSTRACT
Sample preparation is an essential step for nearly every type of biochemical analysis in use today. Among the most important of these analyses is the diagnosis of diseases, since their treatment may rely greatly on time and, in the case of infectious diseases, containing their spread within a population to prevent outbreaks. To address this, many different methods have been developed for use in the wide variety of settings for which they are needed. In this work, we have reviewed the literature and report on a broad range of methods that have been developed in recent years and their applications to point-of-care (POC), high-throughput screening, and low-resource and traditional clinical settings for diagnosis, including some of those that were developed in response to the coronavirus disease 2019 (COVID-19) pandemic. In addition to covering alternative approaches and improvements to traditional sample preparation techniques such as extractions and separations, techniques that have been developed with focuses on integration with smart devices, laboratory automation, and biosensors are also discussed.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Specimen Handling / High-Throughput Screening Assays Type of study: Diagnostic study / Observational study / Prognostic study Limits: Humans Language: English Journal subject: Biology Year: 2021 Document Type: Article Affiliation country: Molecules26185666

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Specimen Handling / High-Throughput Screening Assays Type of study: Diagnostic study / Observational study / Prognostic study Limits: Humans Language: English Journal subject: Biology Year: 2021 Document Type: Article Affiliation country: Molecules26185666