Case Report: Paucisymptomatic College-Age Population as a Reservoir for Potentially Neutralization-Resistant Severe Acute Respiratory Syndrome Coronavirus 2 Variants.
Am J Trop Med Hyg
; 105(5): 1227-1229, 2021 09 20.
Article
in English
| MEDLINE | ID: covidwho-1431020
ABSTRACT
To better understand the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant lineage distribution in a college campus population, we carried out viral genome surveillance over a 7-week period from January to March 2021. Among the sequences were three novel viral variants BV-1 with a B.1.1.7/20I genetic background and an additional spike mutation Q493R, associated with a mild but longer-than-usual COVID-19 case in a college-age person, BV-2 with a T478K mutation on a 20B genetic background, and BV-3, an apparent recombinant lineage. This work highlights the potential of an undervaccinated younger population as a reservoir for the spread and generation of novel variants. This also demonstrates the value of whole genome sequencing as a routine disease surveillance tool.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Students
/
Universities
/
Disease Reservoirs
/
SARS-CoV-2
/
COVID-19
/
Mutation
Type of study:
Case report
Topics:
Variants
Limits:
Adult
/
Humans
/
Young adult
Language:
English
Journal:
Am J Trop Med Hyg
Year:
2021
Document Type:
Article
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