Inflammatory Markers and Cytokines in Moderate and Critical Cases of COVID-19.
Clin Lab
; 67(9)2021 Sep 01.
Article
in English
| MEDLINE | ID: covidwho-1431126
ABSTRACT
BACKGROUND:
Inflammatory responses have been suggested to be associated with coronavirus disease 2019 (COVID-19). This study investigated the inflammatory markers and cytokines in COVID-19 according to its severity.METHODS:
We enrolled 49 patients with COVID-19, who were classified as either moderate or critical cases. Serum or plasma interleukin (IL)-1ß, IL-6, and tumor necrosis factor-α (TNF-α) levels were measured.RESULTS:
Lactate dehydrogenase, ferritin, C-reactive protein, and procalcitonin levels were significantly higher in the critical group than in the moderate group (p < 0.001). IL-6 and TNF-α levels were significantly higher in the critical group, with elevated IL-6 levels from the first to third weeks after confirmed PCR (p < 0.05).CONCLUSIONS:
Inflammatory markers and cytokines were increased in COVID-19 and closely related to the severity of the disease. We recommend early active monitoring of IL-6 levels along with inflammatory markers for severe COVID-19.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Cytokines
/
COVID-19
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal subject:
Laboratory Techniques and procedures
Year:
2021
Document Type:
Article
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