Electrophysiological and olfactometric evaluation of long-term COVID-19.
Physiol Rep
; 9(18): e14992, 2021 09.
Article
in English
| MEDLINE | ID: covidwho-1431180
ABSTRACT
COVID-19 is a public health emergency with cases increasing globally. Its clinical manifestations range from asymptomatic and acute respiratory disease to multiple organ dysfunction syndromes and effects of COVID-19 in the long term. Interestingly, regardless of variant, all COVID-19 share impairment of the sense of smell and taste. We would like to report, as far as we know, the first comprehensive neurophysiological evaluation of the long-term effects of SARS-CoV-2 on the olfactory system with potential-related neurological damage. The case report concerns a military doctor, with a monitored health history, infected in April 2020 by the first wave of the epidemic expansion while on military duty in Codogno (Milan). In this subject, we find the electrophysiological signal in the periphery, while its correlate is absent in the olfactory bulb region than in whole brain recordings. In agreement with this result is the lack of metabolic signs of brain activation under olfactory stimulation. Consequently, quantitative and qualitative diagnoses of anosmia were made by means of olfactometric tests. We strongly suggest a comprehensive series of olfactometric tests from the first sign of COVID-19 and subsequent patient assessments. In conclusion, electrophysiological and metabolic tests of olfactory function have made it possible to study the long-term effects and the establishment of neurological consequences.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Anosmia
/
COVID-19
Type of study:
Case report
/
Experimental Studies
/
Prognostic study
/
Qualitative research
Topics:
Long Covid
/
Variants
Limits:
Adult
/
Humans
/
Male
Language:
English
Journal:
Physiol Rep
Year:
2021
Document Type:
Article
Affiliation country:
Phy2.14992
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